Journal article
Characterisation of experimental flowable composites containing fluoride-doped calcium phosphates as promising remineralising materials
Journal of dentistry, Vol.143, pp.104906-104906
04/2024
DOI: 10.1016/j.jdent.2024.104906
PMID: 38428715
Abstract
Remineralising composites with antibacterial properties may seal the cavity and prevent secondary caries. This study aimed at developing experimental flowable composites containing different concentrations of fluoride-doped calcium phosphate fillers and evaluating their remineralising and antibacterial properties.
Experimental resin-based composites containing different concentrations (0–20 %) of fluoride-doped calcium phosphate fillers (VS10/VS20) were formulated. The release of calcium (Ca), phosphate (PO) and fluoride (F) ions was assessed for 30 days. Remineralisation properties were evaluated through ATR-FTIR and SEM/EDX after storage in simulated body fluid (SBF). The metabolic activity and viability of Streptococcus gordonii was also evaluated through ATP, CFU and live/dead confocal microscopy. The evaluation of specific monomer elution from the experimental composites was conducted using high-performance liquid chromatography (HPLC).
The composites containing VS10 showed the highest release of Ca, those containing VS20 released more F over time (p < 0.05), while there was no significant difference in terms of PO ions release between the groups (p > 0.05). A quick 7-day mineral precipitation was observed in the tested composites containing VS10 or VS20 at 10 %; these materials also showed the greatest antibacterial activity (p < 0.05). Moreover, the tested composites containing VS10 presented the lowest elution of monomers (p < 0.05).
Innovative composites were developed with low monomers elution, evident antibacterial activity against S. gordonii and important remineralisation properties due to specific ions release.
Novel composites containing fluoride-doped calcium phosphates may be promising to modulate bacteria growth, promote remineralisation and reduce the risk of cytotoxicity related to monomers’ elution.
Details
- Title: Subtitle
- Characterisation of experimental flowable composites containing fluoride-doped calcium phosphates as promising remineralising materials
- Creators
- Adrián M. Alambiaga-Caravaca - Royal College of Surgeons in IrelandYu Fu Chou - Universidad Cardenal Herrera CEUDaniel Moreno - Universitat Internacional de CatalunyaConrado Aparicio - Institute for Bioengineering of CataloniaAlicia López-Castellano - Universidad Cardenal Herrera CEUVictor Pinheiro Feitosa - University of IowaArzu Tezvergil-Mutluay - University of TurkuSalvatore Sauro - Universidad Cardenal Herrera CEU
- Resource Type
- Journal article
- Publication Details
- Journal of dentistry, Vol.143, pp.104906-104906
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.jdent.2024.104906
- PMID
- 38428715
- ISSN
- 0300-5712
- eISSN
- 1879-176X
- Language
- English
- Date published
- 04/2024
- Academic Unit
- Operative Dentistry
- Record Identifier
- 9984655346802771
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