Characteristics and risk factors of preterm births in a tertiary center in Lagos, Nigeria

Azeez Butali; Chinyere Ezeaka; Osayame Ekhaguere; Nancy Weathers; Jenna Ladd; Iretiola Fajolu; Christopher Esezobor; Christian Makwe; Bukola Odusanya; Rose Anorlu; Wasiu Adeyemo; Edna Iroha; Mathias Egri-Okwaji; Prisca Adejumo; Lawal Oyeneyin; Moses Abiodun; Bolaji Badejoko; Kelli Ryckman

doi:10.11604/pamj.2016.24.1.8382

Back

Characteristics and risk factors of preterm births in a tertiary center in Lagos, Nigeria

Journal article

Open access

Peer reviewed

Characteristics and risk factors of preterm births in a tertiary center in Lagos, Nigeria

Azeez Butali, Chinyere Ezeaka, Osayame Ekhaguere, Nancy Weathers, Jenna Ladd, Iretiola Fajolu, Christopher Esezobor, Christian Makwe, Bukola Odusanya, Rose Anorlu, …

The Pan African medical journal, Vol.24, pp.1-1

2016

DOI: 10.11604/pamj.2016.24.1.8382

PMCID: PMC4992393

PMID: 27583065

Files and links (1)

url

https://doi.org/10.11604/pamj.2016.24.1.8382View

Published (Version of record) Open Access

Abstract

Preterm birth is a dire complication of pregnancy that poses huge long-term medical and financial burdens for affected children, their families, and the health care system. The aim of the present study was to identify characteristics associated with preterm births at the Lagos University Teaching Hospital (LUTH), Lagos, Nigeria from 2011 to 2013. We obtained Information from 5,561 maternal, fetal/neonatal and obstetric records from the labor ward. We excluded delivery at less than 22 weeks (0.25%), post-term birth at ≥42 weeks gestation (1.3%), and unknown gestation (1.4%). Additionally, we excluded records of multiple births (5.4%) and stillbirths (8.3%) leaving 4,691 records of singleton live-births for analysis. Logistic regression analysis was performed comparing preterm birth (22-36 weeks gestation) to term birth (37-41 weeks gestation). Multiple variable models adjusting for maternal age, parity, fetal position, delivery method and booking status were also evaluated. Multinomial regression was used to identify characteristics associated with preterm birth (PTB) defined as early PTB (22-31 weeks gestation), moderate PTB (32-34 weeks gestation), late PTB (35-36 weeks gestation), compared to term birth (37-41 completed weeks gestation). From our data, 16.8% of the singleton live-birth deliveries were preterm (<37 weeks gestation). Of these, 4.7% were early (22-31 weeks), 4.5% were moderate (32-34 weeks) and 7.7% were late (35-36) PTBs. Older maternal age (≥35 years) [odds ratio (OR) = 1.41], hypertension (OR = 3.44) and rupture of membranes (OR = 4.03) were significantly associated with increased odds of PTB. Women being treated for the prevention of mother-to-child transmission of HIV were at a significantly decreased risk for PTB (OR = 0.70). Sixteen percent of women in this cohort were not registered for antenatal care in LUTH. These non-registered subjects had significantly greater odds of all categories of PTB, including early (odds ratio (OR) = 20.8), moderate (OR = 8.68), and late (OR = 2.15). PTB and risks for PTB remain high in Nigeria. We recommend that any high risk pregnancy should be referred to a tertiary center for prenatal care in order to significantly reduce adverse birth outcomes such as PTBs.

Pregnancy

Prenatal Care - statistics & numerical data

Humans

Risk Factors

Hospitals, University

Logistic Models

Male

Premature Birth - epidemiology

Gestational Age

Premature Birth - etiology

Young Adult

Maternal Age

Adolescent

Nigeria - epidemiology

Adult

Female

Pregnancy Complications - epidemiology

Details

Title: Subtitle: Characteristics and risk factors of preterm births in a tertiary center in Lagos, Nigeria
Creators: Azeez Butali - Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, IA, USA
Chinyere Ezeaka - Department of Pediatrics, College of Medicine, University of Lagos, Nigeria
Osayame Ekhaguere - Department of Pediatrics, University of Iowa, IA, USA
Nancy Weathers - Department of Pediatrics, University of Iowa, IA, USA
Jenna Ladd - University of Iowa
Iretiola Fajolu - Department of Pediatrics, College of Medicine, University of Lagos, Nigeria
Christopher Esezobor - Department of Pediatrics, College of Medicine, University of Lagos, Nigeria
Christian Makwe - Department of Obstetrics and Gynecology, College of Medicine, University of Lagos, Nigeria
Bukola Odusanya - Department of Pediatrics, College of Medicine, University of Lagos, Nigeria
Rose Anorlu - Department of Pediatrics, College of Medicine, University of Lagos, Nigeria
Wasiu Adeyemo - Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos, Nigeria
Edna Iroha - Department of Pediatrics, College of Medicine, University of Lagos, Nigeria
Mathias Egri-Okwaji - Department of Pediatrics, College of Medicine, University of Lagos, Nigeria
Prisca Adejumo - Department of Nursing, University of Ibadan, Nigeria
Lawal Oyeneyin - Department of Obstetrics and Gynecology, Mother and Child Hospital Ondo, Ondo, Nigeria
Moses Abiodun - Department of Pediatrics, Mother and Child Hospital Ondo, Ondo, Nigeria
Bolaji Badejoko - Department of Pediatrics, Mother and Child Hospital Ondo, Ondo, Nigeria
Kelli Ryckman - Department of Epidemiology, College of Public Health, University of Iowa, IA, USA
Resource Type: Journal article
Publication Details: The Pan African medical journal, Vol.24, pp.1-1
DOI: 10.11604/pamj.2016.24.1.8382
PMID: 27583065
PMCID: PMC4992393
NLM abbreviation: Pan Afr Med J
ISSN: 1937-8688
eISSN: 1937-8688
Publisher: Uganda
Grant note: R00 DE022378 / NIDCR NIH HHS R00 HD065786 / NICHD NIH HHS K99 HD065786 / NICHD NIH HHS
Language: English
Date published: 2016
Academic Unit: Oral Pathology, Radiology and Medicine; Stead Family Department of Pediatrics; Epidemiology; Craniofacial Anomalies Research Center; Dental Research
Record Identifier: 9983995040002771

Metrics

47 Record Views