Journal article
Characteristics and utilisation of the Mayo Clinic Biobank, a clinic-based prospective collection in the USA: cohort profile
BMJ open, Vol.9(11), pp.e032707-e032707
11/01/2019
DOI: 10.1136/bmjopen-2019-032707
PMCID: PMC6858142
PMID: 31699749
Abstract
Purpose The Mayo Clinic Biobank was established to provide a large group of patients from which comparison groups (ie, controls) could be selected for case-control studies, to create a prospective cohort with sufficient power for common outcomes and to support electronic health record (EHR) studies.
Participants A total of 56 862 participants enrolled (21% response rate) into the Mayo Clinic Biobank from Rochester, Minnesota (77%, n=43 836), Jacksonville, Florida (18%, n=10 368) and La Crosse, Wisconsin (5%, n=2658). Participants were all Mayo Clinic patients, 18 years of age or older and US residents.
Findings to date Overall, 43% of participants were 65 years of age or older and female participants were more frequent (59%) than males at all sites. Most participants resided in the Upper Midwest regions of the USA (Minnesota, Iowa, Illinois or Wisconsin), Florida or Georgia. Self-reported race among Biobank participants was 90% white. Here we provide examples of the types of studies that have successfully utilised the resource, including (1) investigations of the population itself, (2) provision of controls for case-control studies, (3) genotype-driven research, (4) EHR-based research and (5) prospective recruitment to other studies. Over 270 projects have been approved to date to access Biobank data and/or samples; over 200 000 sample aliquots have been approved for distribution.
Future plans The data and samples in the Mayo Clinic Biobank can be used for various types of epidemiological and clinical studies, especially in the setting of case-control studies for which the Biobank samples serve as control samples. We are planning cohort studies with additional follow-up and acquisition of genetic information on a large scale.
Details
- Title: Subtitle
- Characteristics and utilisation of the Mayo Clinic Biobank, a clinic-based prospective collection in the USA: cohort profile
- Creators
- Janet E. Olson - Mayo ClinicEuijung Ryu - Mayo ClinicMatthew A. Hathcock - Mayo ClinicRuchi Gupta - Mayo ClinicJoshua T. Bublitz - Mayo ClinicPaul Y. Takahashi - Mayo ClinicSuzette J. Bielinski - Mayo ClinicJennifer L. St Sauver - Mayo Clin, Dept Hlth Sci Res, Div Epidemiol, Rochester, MN 55905 USAKaren Meagher - Mayo ClinicRichard R. Sharp - Mayo ClinicStephen N. Thibodeau - Mayo ClinicMine Cicek - Mayo ClinicJames R. Cerhan - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- BMJ open, Vol.9(11), pp.e032707-e032707
- DOI
- 10.1136/bmjopen-2019-032707
- PMID
- 31699749
- PMCID
- PMC6858142
- NLM abbreviation
- BMJ Open
- ISSN
- 2044-6055
- eISSN
- 2044-6055
- Publisher
- Bmj Publishing Group
- Number of pages
- 9
- Grant note
- R01AG034676 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Mayo Clinic Center for Individualized Medicine
- Language
- English
- Date published
- 11/01/2019
- Academic Unit
- Epidemiology
- Record Identifier
- 9984368217602771
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