Journal article
Characteristics of Mammographic Breast Density and Associated Factors for Chinese Women: Results from an Automated Measurement
Journal of oncology, Vol.2019, pp.4910854-9
01/01/2019
DOI: 10.1155/2019/4910854
PMCID: PMC6444251
PMID: 31015834
Abstract
Background. Characteristics of mammographic density for Chinese women are understudied. This study aims to identify factors associated with mammographic density in China using a quantitative method. Methods. Mammographic density was measured for a total of 1071 (84 with and 987 without breast cancer) women using an automatic algorithm AutoDensity. Pearson tests examined relationships between density and continuous variables and t-tests compared differences of mean density values between groupings of categorical variables. Linear models were built using multiple regression. Results. Percentage density and dense area were positively associated with each other for cancer-free (r=0.487, p<0.001) and cancer groups (r=0.446, p<0.001), respectively. For women without breast cancer, weight and BMI (p<0.001) were found to be negatively associated (r=-0.237, r=-0.272) with percentage density whereas they were found to be positively associated (r=0.110, r=0.099) with dense area; age at mammography was found to be associated with percentage density (r=-0.202, p<0.001) and dense area (r=-0.086, p<0.001) but did not add any prediction within multivariate models; lower percentage density was found within women with secondary education background or below compared to women with tertiary education. For women with breast cancer, percentage density demonstrated similar relationships with that of cancer-free women whilst breast area was the only factor associated with dense area (r=0.739, p<0.001). Conclusion. This is the first time that mammographic density was measured by a quantitative method for women in China and identified associations should be useful to health policy makers who are responsible for introducing effective models of breast cancer prevention and diagnosis.
Details
- Title: Subtitle
- Characteristics of Mammographic Breast Density and Associated Factors for Chinese Women: Results from an Automated Measurement
- Creators
- Tong Li - University of Sydney Faculty of Health SciencesLichen Tang - Fudan University Shanghai Cancer CenterZiba Gandomkar - University of Sydney Faculty of Health SciencesRob Heard - Univ Sydney, Fac Hlth Sci, Behav & Social Sci, Cumberland Campus,75 East St, Lidcombe, NSW, AustraliaClaudia Mello-Thoms - University of Sydney Faculty of Health SciencesQin Xiao - Fudan University Shanghai Cancer CenterYajia Gu - Fudan University Shanghai Cancer CenterGenhong Di - Fudan University Shanghai Cancer CenterCarolyn Nickson - University of MelbourneZhimin Shao - Fudan Univ, Shanghai Canc Ctr, Key Lab Breast Canc Shanghai, Dept Breast Surg, 270 Dongan Rd, Shanghai, Peoples R ChinaPatrick Brennan - The University of Sydney
- Resource Type
- Journal article
- Publication Details
- Journal of oncology, Vol.2019, pp.4910854-9
- DOI
- 10.1155/2019/4910854
- PMID
- 31015834
- PMCID
- PMC6444251
- NLM abbreviation
- J Oncol
- ISSN
- 1687-8450
- eISSN
- 1687-8450
- Publisher
- Hindawi Publishing Group
- Number of pages
- 9
- Language
- English
- Date published
- 01/01/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology
- Record Identifier
- 9984318697802771
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