Journal article
Characteristics of core promoter and precore stop codon mutants of hepatitis B virus in Vietnam
Journal of medical virology, Vol.74(2), pp.228-236
10/2004
DOI: 10.1002/jmv.20175
PMID: 15332271
Abstract
In Asia, genotypes B and C are the most common genotypes of hepatitis B virus (HBV); and genotype C causes more severe liver disease. Core promoter/precore (CP/PC) mutants, known to be linked to these genotypes, could have an impact on the progression and severity of liver disease. Sera of 115 patients, including 39 acute and 76 chronic Vietnamese HBV infected patients, were tested for their liver profile, HBeAg, HBV genotypes, and HBV DNA level. Fragments of 282 nucleotides covering CP/PC were amplified, sequenced, and analysed. In the acute group, CP/PC mutants accounted for 38.4 and 25.6%, respectively. Genotype B was found to be predominant (74.3%, P < 0.05) and linked to the PC mutant (A1896) (P < 0.05). In the chronic group, CP/PC mutants accounted for 61.7 and 32.8%. CP mutants, especially the T1762/A1764 double mutant, were found to correlate with genotype C (81%, P < 0.001), liver cirrhosis, and hepatocellular carcinoma (P < 0.05). Therefore, genotype C in Vietnam, which carried high rate of C-1858 (70%), could play an important role in causing severe chronic liver disease.
Details
- Title: Subtitle
- Characteristics of core promoter and precore stop codon mutants of hepatitis B virus in Vietnam
- Creators
- Tran Thien Tuan Huy - Department of Pathology, National Institute of Infectious Diseases, Tokyo, JapanHiroshi Ushijima - Department of Developmental Medical Sciences, Graduate School of Medicine, University of Tokyo, Tokyo, JapanVo Xuan Quang - Department of Gastroentero-Hepatology, Cho Ray Hospital, Ho Chi Minh City, VietnamTrinh Thi Ngoc - National Institute for Clinical Research in Tropical Medicine, Bach Mai Hospital, Hanoi, VietnamShigeki Hayashi - National Disaster Medical Center, Tokyo, JapanTetsutaro Sata - Department of Pathology, National Institute of Infectious Diseases, Tokyo, JapanKenji Abe - Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
- Resource Type
- Journal article
- Publication Details
- Journal of medical virology, Vol.74(2), pp.228-236
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- DOI
- 10.1002/jmv.20175
- PMID
- 15332271
- ISSN
- 0146-6615
- eISSN
- 1096-9071
- Number of pages
- 9
- Language
- English
- Date published
- 10/2004
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984094495802771
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