Characteristics of hepatitis B virus in Ghana: full length genome sequences indicate the endemicity of genotype E in West Africa

Tran Thien Tuan Huy; Koichi Ishikawa; William Ampofo; Taku Izumi; Akira Nakajima; Justina Ansah; John O Tetteh; Nicholas Nii-Trebi; Simeon Aidoo; David Ofori-Adjei; Tetsutaro Sata; Hiroshi Ushijima; Kenji Abe

doi:10.1002/jmv.20525

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Characteristics of hepatitis B virus in Ghana: full length genome sequences indicate the endemicity of genotype E in West Africa

Journal article

Peer reviewed

Characteristics of hepatitis B virus in Ghana: full length genome sequences indicate the endemicity of genotype E in West Africa

Tran Thien Tuan Huy, Koichi Ishikawa, William Ampofo, Taku Izumi, Akira Nakajima, Justina Ansah, John O Tetteh, Nicholas Nii-Trebi, Simeon Aidoo, David Ofori-Adjei, …

Journal of medical virology, Vol.78(2), pp.178-184

02/2006

DOI: 10.1002/jmv.20525

PMID: 16372296

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Abstract

Hepatitis B virus (HBV) genotypes from A to H have distinct geographical distributions and have been shown to affect the clinical features as well as the course of the HBV infection. HBV genotype E has been found only in Africa. However, the complete genomes of this genotype, which were isolated mainly from West Africa, were available only for a few samples. In this study, five full-length genomes and seven other small S genes of HBV strains from Ghanaian blood donors were sequenced and investigated. Following phylogenetic analysis, all of the Ghanaian HBV strains were clustered closely in genotype E. All of the 12 small S genes showed the same characteristic of subtype ayw4. The complete genomes of the five Ghanaian strains showed marked similarity with each other and with the reported genotype E strains (96.7%-99.1%). Genotype E strains showed low intra-genotypic diversity (1.8%) and carried the conserved signature pattern in pre-S1 as well as in the full genome sequence. Of note, the finding of the G145R escape mutant in an unvaccinated Ghanaian blood donor might raise concern as to the ongoing nation-wide hepatitis B vaccination program in Ghana.

Amino Acid Sequence

Genome, Viral

Viral Envelope Proteins - genetics

Species Specificity

Humans

Hepatitis B - virology

Molecular Sequence Data

Ghana

Genetic Variation

Sequence Homology, Amino Acid

Blood Donors

Genes, Viral

Hepatitis B virus - genetics

Mutation

Details

Title: Subtitle: Characteristics of hepatitis B virus in Ghana: full length genome sequences indicate the endemicity of genotype E in West Africa
Creators: Tran Thien Tuan Huy - Department of Pathology, National Institute of Infectious Diseases, Toyama, Tokyo, Japan
Koichi Ishikawa
William Ampofo
Taku Izumi
Akira Nakajima
Justina Ansah
John O Tetteh
Nicholas Nii-Trebi
Simeon Aidoo
David Ofori-Adjei
Tetsutaro Sata
Hiroshi Ushijima
Kenji Abe
Resource Type: Journal article
Publication Details: Journal of medical virology, Vol.78(2), pp.178-184
DOI: 10.1002/jmv.20525
PMID: 16372296
ISSN: 0146-6615
eISSN: 1096-9071
Language: English
Date published: 02/2006
Academic Unit: Gastroenterology and Hepatology; Internal Medicine
Record Identifier: 9984094732502771

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