Journal article
Characteristics of patients with nonarteritic anterior ischemic optic neuropathy eligible for the Ischemic Optic Neuropathy Decompression Trial
Archives of ophthalmology (1960), Vol.114(11), pp.1366-1374
11/01/1996
DOI: 10.1001/archopht.1996.01100140566007
PMID: 8906027
Abstract
OBJECTIVETo describe the baseline clinical characteristics of patients in the Ischemic Optic Neuropathy Decompression Trial (IONDT).DESIGNThe IONDT is a single-masked, multicenter, randomized clinical trial.SETTINGSTwenty-five US clinical centers.PATIENTSEligibility criteria for randomization to either optic nerve sheath decompression surgery or careful follow-up included a diagnosis of acute unilateral nonarteritic anterior ischemic optic neuropathy (NAION), a visual acuity of 20/64 or worse and better than no light perception, and an age of 50 years or older. Patients who were eligible except for having visual acuity better than 20/64 were not randomized, but were followed up.METHODSEach patient underwent a standardized history and examination by certified study personnel within 14 days of the onset of symptoms. Masked personnel performed outcome measurements.RESULTSOf 420 patients with NAION, 258 were randomized, and 162 were not randomized and are being followed up. Sixty-two percent of the patients were men and 95% were white. The mean +/- SD age at onset was 66.0 +/- 8.7 years. Hypertension was reported in 47% of the patients in the IONDT, and 24% of the patients had diabetes mellitus. Forty-two percent of the patients recalled the onset of visual symptoms to be within 2 hours of awakening. Initial visual acuities in the study eye ranged from 20/20 or better to light perception, with 49% of the patients seeing better than 20/64 and 34% of the patients seeing 20/200 or worse. The mean Westergren sedimentation rate was 18.4 mm/h, with 9% of the patients having a rate greater than 40 mm/h. The nonrandomized patients (visual acuity better than 20/64) were younger, 72% were male, and they had a lower prevalence of hypertension and diabetes mellitus.CONCLUSIONAlthough our baseline findings are derived from a selected population of patients with NAION who were eligible for the IONDT, they provide the first description of NAION from a large prospective study that used a standard definition of NAION and only included patients who were identified within 2 weeks of the onset of symptoms.
Details
- Title: Subtitle
- Characteristics of patients with nonarteritic anterior ischemic optic neuropathy eligible for the Ischemic Optic Neuropathy Decompression Trial
- Creators
- Nancy J Newman - Emory UniversitySophia Chung - Anheuser-Busch Eye Institute, St Louis (Mo) University Health Sciences CenterKay Dickersin - Coordinating Center, University of Maryland, School of MedicineSonia Armstrong - Carolinas Medical CenterPatricia Jones - State University of New YorkMichael Graham - State University of New YorkRichard Anderson - University of UtahCharlene Campbell - West Virginia UniversityDavid Kaufman - Michigan State UniversityShalom Kelman - University of Maryland, University of Maryland School of MedicineRoberta Scherer - Coordinating Center, University of Maryland, School of MedicineJohn Kennerdell - Allegheny General HospitalAnna Tyutyunikov - Allegheny General HospitalRussell Edwards - Allegheny General HospitalTodd Goodglick - Allegheny General HospitalDeborah Lang - Allegheny General HospitalJohn Seihorst - Anheuser-Busch Eye Institute, St Louis (Mo) University Health Sciences CenterKimberly Peele - Allegheny General HospitalYvonne McCracken - Carolinas Medical CenterMark Malton - Carolinas Medical CenterPatty Knaup - Anheuser-Busch Eye Institute, St Louis (Mo) University Health Sciences CenterJohn Holds - Anheuser-Busch Eye Institute, St Louis (Mo) University Health Sciences CenterEugene Benjamin - Carolinas Medical CenterDiana Mekelburg - Anheuser-Busch Eye Institute, St Louis (Mo) University Health Sciences CenterEvelyn Brooks - Carolinas Medical CenterCarol Dellinger - Carolinas Medical CenterTraci Hunter Medlin - Carolinas Medical CenterBarbara Kmsler - Carolinas Medical CenterMike McOwen - Carolinas Medical CenterDonna Russell - Carolinas Medical CenterTimothy Saunders - Carolinas Medical CenterGregory Kosmorsky - Cleveland (Ohio) Clinic FoundationTina Kiss - Cleveland (Ohio) Clinic FoundationCate Reinhard - Cleveland (Ohio) Clinic FoundationJanet Edgerton - Cleveland (Ohio) Clinic FoundationTami Fecko - Cleveland (Ohio) Clinic FoundationSusannah Hanson - Cleveland (Ohio) Clinic FoundationPamela Vargo - Cleveland (Ohio) Clinic FoundationBrian Kraus - Cleveland (Ohio) Clinic FoundationLaura Walsh - Cleveland (Ohio) Clinic FoundationRufus Willis - Cleveland (Ohio) Clinic FoundationDeborah Ross - Cleveland (Ohio) Clinic FoundationNancy Tomsak - Cleveland (Ohio) Clinic FoundationSteven Feldon - Doheny Eye InstituteLori Levin - Doheny Eye InstituteKerry Zimmerman - Doheny Eye InstituteKristin Anderson - Doheny Eye InstituteRichard Cortez - Doheny Eye InstituteKaren Deblanc - Doheny Eye InstituteJudy Hülse - Doheny Eye InstituteRichard Morales - Doheny Eye InstituteTracy Nichols - Doheny Eye InstituteLillian Reyes - Doheny Eye InstituteNadine Rodarte-Ochoa - Doheny Eye InstituteDaniel Romo - Doheny Eye InstituteAlfredo Sadun - Doheny Eye InstituteMary Steber - Doheny Eye InstituteFrances Walonker - Doheny Eye InstituteDonna Loupe - Emory UniversityDiana Coffman - Emory UniversityHarvey Cole - Emory UniversityTed Wojno - Emory UniversityBarry Skarf - Henry Ford HospitalColleen Wojtala - Henry Ford HospitalMark Croswell - Henry Ford HospitalWendy Gilroy - Henry Ford HospitalChristian Mageli - Henry Ford HospitalDena McDonald - Henry Ford HospitalGeorge Ponka - Henry Ford HospitalRosa Tang - University of TexasMelissa Hamlin - University of TexasJewel Curtis - University of TexasKenneth Hyde - University of TexasKirk Mack - University of TexasPortia Tello - University of TexasAnthony Arnold - Jules Stein Eye InstituteMargaret Mullen - Jules Stein Eye InstituteAnne Bolton - Jules Stein Eye InstituteBemice Cibener - Jules Stein Eye InstituteJesus Garcia - Jules Stein Eye InstituteMelody Vega - Jules Stein Eye InstituteRobert Goldberg - Jules Stein Eye InstituteBobbi Ballenberg - Jules Stein Eye InstituteLynn Gordon - Jules Stein Eye InstituteMichael Heneghan - Jules Stein Eye InstituteHoward Krauss - Jules Stein Eye InstituteJackie Sanguinei - Jules Stein Eye InstituteRobert Stalling - Jules Stein Eye InstituteJenja Yadegaran - Jules Stein Eye InstituteWayne Cornblath - W. K. Kellogg Eye Center, University of MichiganBarbara Michael - W. K. Kellogg Eye Center, University of MichiganDonna Campbell - W. K. Kellogg Eye Center, University of MichiganCheryl Caudill - W. K. Kellogg Eye Center, University of MichiganChristine Nelson - W. K. Kellogg Eye Center, University of MichiganJonathan Trobe - W. K. Kellogg Eye Center, University of MichiganLenworth N Johnson - Mason Institute of Ophthalmology, University of MissouriGaye Baker - Mason Institute of Ophthalmology, University of MissouriCoy Cobb - Mason Institute of Ophthalmology, University of MissouriPhilip Custer - Mason Institute of Ophthalmology, University of MissouriSharon Turner - Mason Institute of Ophthalmology, University of MissouriRoy Wilson - Mason Institute of Ophthalmology, University of MissouriBrian Younge - Mayo ClinicJacqueline Leavitt - Mayo ClinicRebecca Nielsen - Mayo ClinicJody Allen - Mayo ClinicBarbara Eickhoff - Mayo ClinicJames Garrity - Mayo ClinicJacqueline Ladsten - Mayo ClinicKathleen Lebarron - Mayo ClinicThomas Link - Mayo ClinicJay Rostvold - Mayo ClinicKaren Weber - Mayo ClinicWarren Felton - Medical College of VirginiaTracy Oliver - Medical College of VirginiaDanielle Gabriel - Medical College of VirginiaSylvia Smith - Medical College of VirginiaDaniel David - Medical College of VirginiaLahn Fendelander - Medical College of VirginiaDaniel Geller - Medical College of VirginiaTimothy Jordan - Medical College of VirginiaChristian Kim - Medical College of VirginiaCraig Munger - Medical College of VirginiaJo Anne Romandy - Medical College of VirginiaGeorge Sanborn - Medical College of VirginiaBradley Schwartz - Medical College of VirginiaCarl Sheusi - Medical College of VirginiaConstance Smith - Medical College of VirginiaKathy Talley - Medical College of VirginiaSandya Thimmappa - Medical College of VirginiaEric Eggenberger - Michigan State UniversitySuzanne Bickert - Michigan State UniversityRobert Granadier - Michigan State University, William Beaumont HospitalSandra Holliday - Michigan State UniversityThomas Moore - Michigan State UniversityJaya Varadarajan - Michigan State UniversityDeborah Friedman - State University of New YorkHaris Amin - State University of New YorkThomas Bersani - State University of New YorkCynthia Briglin - State University of New YorkJames Fooks - State University of New YorkMilton James - State University of New YorkGary Michalec - State University of New YorkHoang Nguyen - State University of New YorkJonathan Horton - University of CaliforniaMaeve Chang - University of CaliforniaLou Anne Aber - University of CaliforniaErik Lindstrom - University of CaliforniaStuart Seiff - University of CaliforniaJohn Guy - University of FloridaZ. Suzanne Zam - University of FloridaAmye Francis - University of FloridaLatif Hamed - University of FloridaAlan Lessner - University of FloridaDonna McDavid - University of FloridaDiana Shamis - University of FloridaJames Goodwin - University of IllinoisMartin E Lindeman - University of IllinoisErlinda Sullivan - University of IllinoisPhyllis Bobak - University of IllinoisAllen Putterman - University of IllinoisRobert Baker - University of KentuckyJudy Beck - University of KentuckyDavid Cowen - University of KentuckyAvrom Epstein - University of KentuckyMichael Hanson - University of KentuckyToni Scoggins - University of KentuckyCharlotte Frank - University of Maryland, University of Maryland School of MedicineAndrea Blake - University of Maryland, University of Maryland School of MedicineAnn M Rodavitch - University of Maryland, University of Maryland School of MedicineBrenda Gore - University of MarylandMichelle Heroux - University of MarylandRani Kalsi - University of MarylandCharlene Krauch - University of MarylandMary Ann Millar - University of MarylandKakarla Chalam - University of South CarolinaMitchell Wolin - University of South CarolinaBeth Munn - University of South CarolinaRita Jean Brady - University of South CarolinaBarbara Danner - University of South CarolinaRegina Hansen - University of South CarolinaMichael Briggs - University of South CarolinaBeverly Simons - University of South CarolinaAnne Stewart - University of South CarolinaKathleen Digre - University of UtahJodi Erickson - University of UtahLizbeth Malmquist-Webb - University of UtahTerrell Blackburn - University of UtahSusan Baggaley - University of UtahCharles Juarez - University of UtahBonnie Kaye - University of UtahPaul Langer - University of UtahAditya Mishra - University of UtahPaula Morris - University of UtahSandra Osborn - University of UtahBhupendra Patel - University of UtahSandra Staker - University of UtahJudith Warner - University of UtahSteven Newman - University of VirginiaChristine Evans - University of VirginiaAllison Aylor - University of VirginiaCarolyn Childress - University of VirginiaHelen Dickerson - University of VirginiaJane Fleming - University of VirginiaNomine Harris - University of VirginiaL. Sharon Hoyle - University of VirginiaEllen Murphy - University of VirginiaJames Scott - University of VirginiaTerri Small - University of VirginiaKaren Summerville - University of VirginiaMariann Terrell - University of VirginiaLillian Tyler - University of VirginiaJohn Linberg - West Virginia UniversityBrian Ellis - West Virginia UniversityLenore Breen - West Virginia UniversityMichelle Michael - West Virginia UniversityNancy Groves - West Virginia UniversityRobert Hobson - West Virginia UniversityGordon McGregor - West Virginia UniversityLaura Shepherd - West Virginia UniversityEdward Cohn - William Beaumont HospitalKristi Cummings - William Beaumont HospitalPatricia Manatrey - William Beaumont HospitalSara Casey - William Beaumont HospitalJohn Johnson - William Beaumont HospitalColetti Kronner - William Beaumont HospitalVirginia Regan - William Beaumont HospitalPatricia Streasick - William Beaumont HospitalMichael Elman - University of Maryland School of Medicine, Coordinating Center, University of Maryland, School of MedicineDeborah Metzel - University of Maryland School of MedicineFrank Hooper - Coordinating Center, University of Maryland, School of MedicineBarbara Crawley - Coordinating Center, University of Maryland, School of MedicineCheryl Hiner - Coordinating Center, University of Maryland, School of MedicineLucy Howard - Coordinating Center, University of Maryland, School of MedicinePatricia Langenberg - Coordinating Center, University of Maryland, School of MedicineOlga Lurye - Coordinating Center, University of Maryland, School of MedicineJanet Masiero - Coordinating Center, University of Maryland, School of MedicineRobert McCarter - Coordinating Center, University of Maryland, School of MedicineSara Riedel - Coordinating Center, University of Maryland, School of MedicineMichelle Sotos - Coordinating Center, University of Maryland, School of MedicineLaureen Spioch - Coordinating Center, University of Maryland, School of MedicineJoann Starr - Coordinating Center, University of Maryland, School of MedicineJudy Urban - Coordinating Center, University of Maryland, School of MedicineMark Waring - Coordinating Center, University of Maryland, School of MedicineP David Wilson - Coordinating Center, University of Maryland, School of MedicineDonald Everett - National Eye InstitutePhil AitkenRoy BeckAndrea LacroixSimmons LessellRev Kenneth Maclean
- Resource Type
- Journal article
- Publication Details
- Archives of ophthalmology (1960), Vol.114(11), pp.1366-1374
- DOI
- 10.1001/archopht.1996.01100140566007
- PMID
- 8906027
- NLM abbreviation
- Arch Ophthalmol
- ISSN
- 0003-9950
- eISSN
- 1538-3601
- Publisher
- American Medical Association
- Language
- English
- Date published
- 11/01/1996
- Academic Unit
- Neurology; Ophthalmology and Visual Sciences
- Record Identifier
- 9984111971602771
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