Journal article
Characterization and acute phase modulation of canine apolipoprotein H (beta 2-glycoprotein I)
Biochemical and biophysical research communications, Vol.191(3), pp.1288-1293
03/31/1993
DOI: 10.1006/bbrc.1993.1357
PMID: 7682067
Abstract
Apolipoprotein H (ApoH) is a 50 kDa glycoprotein capable of binding to negatively charged phospholipids and is a probable inhibitor of the blood coagulation pathway, platelet aggregation, and platelet prothrombinase activity, as well as being involved in autoimmune disease. We have cloned and sequenced a full length ApoH cDNA clone from a beagle dog liver library. Its derived amino acid sequence shows high cross-species similarity to ApoH from other mammals. Canine ApoH mRNA expression is down regulated during an experimentally induced inflammatory response establishing that it is a negative acute phase reactant.
Details
- Title: Subtitle
- Characterization and acute phase modulation of canine apolipoprotein H (beta 2-glycoprotein I)
- Creators
- G C Sellar - Trinity College DublinJ KeaneH MehdiM E PeeplesN BrowneA S Whitehead
- Resource Type
- Journal article
- Publication Details
- Biochemical and biophysical research communications, Vol.191(3), pp.1288-1293
- DOI
- 10.1006/bbrc.1993.1357
- PMID
- 7682067
- ISSN
- 0006-291X
- eISSN
- 1090-2104
- Grant note
- 00908 / PHS HHS 25586 / PHS HHS
- Language
- English
- Date published
- 03/31/1993
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984359879502771
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