Characterization of Endothelium-Dependent Vasodilation and Vasoconstriction in Coronary Arteries from Spontaneously Hypertensive Rats

Leslie C Fuchs; Dan Nuno; Kathryn G Lamping; Alan Kim Johnson

doi:10.1016/0895-7061(95)00441-6

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Characterization of Endothelium-Dependent Vasodilation and Vasoconstriction in Coronary Arteries from Spontaneously Hypertensive Rats

Journal article

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Characterization of Endothelium-Dependent Vasodilation and Vasoconstriction in Coronary Arteries from Spontaneously Hypertensive Rats

Leslie C Fuchs, Dan Nuno, Kathryn G Lamping and Alan Kim Johnson

American journal of hypertension, Vol.9(5), pp.475-483

05/1996

DOI: 10.1016/0895-7061(95)00441-6

PMID: 8735179

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Abstract

Coronary artery disease often occurs in patients with hypertension. The present study was designed to evaluate coronary vascular function in isolated coronary arteries of spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats and to determine the effect of antihypertensive treatment on coronary vascular responsiveness. Male SHR and WKY rats (12 to 14 weeks old) were divided into control and hydralazine-treated (120 mg/L drinking water for 10 days) groups. After 10 days, arterial pressure and heart rate were recorded while rats were conscious and unrestrained. Left ventricular coronary arteries (200 to 300 μm diameter) were isolated and intraluminal diameter was continuously recorded while vessels were maintained at a constant intraluminal pressure of 40 mm Hg. Relaxation of coronary arteries to both acetylcholine and nitroprusside was slightly, but significantly, enhanced in vessels from SHR compared to WKY rats. The enhanced relaxation was a specific effect, since isoproterenol induced similar relaxation in coronary arteries from SHR and WKY rats. Contraction to phenylephrine, but not endothelin-1, was augmented in coronary arteries from SHR compared to WKY rats. Treatment with hydralazine significantly lowered arterial pressure in SHR and WKY rats, but did not alter the enhanced contraction to phenylephrine or the enhanced relaxation to acetylcholine and nitroprusside in coronary arteries from SHR. These results indicate that coronary arteries of 12 to 14 week-old SHR do not have impaired endothelium-dependent relaxation, but do exhibit enhanced α-adrenoreceptor-mediated contraction that is not reduced by lowering arterial pressure.

hydralazine

phenylephrine

Spontaneously hypertensive rats

acetylcholine

isoproterenol

Wistar-Kyoto rats

endothelin-1

coronary arterioles

Details

Title: Subtitle: Characterization of Endothelium-Dependent Vasodilation and Vasoconstriction in Coronary Arteries from Spontaneously Hypertensive Rats
Creators: Leslie C Fuchs - Departments of Pharmacology, Internal Medicine, Psychology and Cardiovascular Center, University of Iowa, Iowa City, Iowa, USA
Dan Nuno - Departments of Pharmacology, Internal Medicine, Psychology and Cardiovascular Center, University of Iowa, Iowa City, Iowa, USA
Kathryn G Lamping - Departments of Pharmacology, Internal Medicine, Psychology and Cardiovascular Center, University of Iowa, Iowa City, Iowa, USA
Alan Kim Johnson - Departments of Pharmacology, Internal Medicine, Psychology and Cardiovascular Center, University of Iowa, Iowa City, Iowa, USA
Resource Type: Journal article
Publication Details: American journal of hypertension, Vol.9(5), pp.475-483
DOI: 10.1016/0895-7061(95)00441-6
PMID: 8735179
NLM abbreviation: Am J Hypertens
ISSN: 0895-7061
eISSN: 1879-1905
Publisher: Oxford University Press
Language: English
Date published: 05/1996
Academic Unit: Psychological and Brain Sciences; Cardiovascular Medicine; Neuroscience and Pharmacology; Health, Sport, and Human Physiology ; Internal Medicine
Record Identifier: 9984094768402771

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