Journal article
Characterization of FGF21 Sites of Production and Signaling in Mice
Endocrinology (Philadelphia), Vol.165(11), bqae120
09/26/2024
DOI: 10.1210/endocr/bqae120
PMID: 39253796
Abstract
Abstract Fibroblast growth factor 21 (FGF21) is an endocrine hormone which signals to multiple tissues to regulate metabolism. FGF21 and another endocrine FGF, fibroblast growth factor 15/19 (FGF15/19), signal to target tissues by binding to the co-receptor β-klotho (KLB), which then facilitates the interaction of these different FGFs with their preferred FGF receptor. KLB is expressed in multiple metabolic tissues, but the specific cell types and spatial distribution of these cells are not known. Furthermore, while circulating FGF21 is primarily produced by the liver, recent publications have indicated that brain derived FGF21 impacts memory and learning. Here, we use reporter mice to comprehensively assess KLB and FGF21 expression throughout the body. These data provide an important resource for guiding future studies to identify important peripheral and central targets of FGFs and to determine the significance of non-hepatic FGF21 production.
Details
- Title: Subtitle
- Characterization of FGF21 Sites of Production and Signaling in Mice
- Creators
- Andrew I Sullivan - University of IowaSharon O Jensen-Cody - University of IowaKristin E Claflin - University of IowaKai E Vorhies - University of IowaKyle H Flippo - University of IowaMatthew J Potthoff - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Endocrinology (Philadelphia), Vol.165(11), bqae120
- DOI
- 10.1210/endocr/bqae120
- PMID
- 39253796
- NLM abbreviation
- Endocrinology
- ISSN
- 1945-7170
- eISSN
- 1945-7170
- Publisher
- ENDOCRINE SOC
- Grant note
- National Institutes of Health: R01DK106104, R01AA027654, R01AG083950, T32 DK112751 Veterans Affairs Merit Review Program: I01BX004634
This work was funded by the National Institutes of Health R01DK106104 (M.J.P.), R01AA027654 (M.J.P.), R01AG083950 (M.J.P.), T32 DK112751 (K.H.F.), and the Veterans Affairs Merit Review Program I01BX004634 (M.J.P.). M.J.P. is also supported by the Roy J. Carver Charitable Trust. The authors would also like to acknowledge the use of the University of Iowa Central Microscopy Research Facility, which is supported by the University of Iowa Vice President for Research and/or the Carver College of Medicine.
- Language
- English
- Electronic publication date
- 09/10/2024
- Date published
- 09/26/2024
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984702957902771
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