Journal article
Characterization of R2and tissue density in the human lung: Application to neonatal imaging in the intensive care unit
Magnetic resonance in medicine, Vol.84(2), pp.920-927
08/01/2020
DOI: 10.1002/mrm.28137
PMCID: PMC7180096
PMID: 31855294
Abstract
Purpose Novel demonstration of R2* and tissue density estimation in infant lungs using 3D ultrashort echo time MRI. Differences between adult and neonates with no clinical indication of lung pathology is explored, as well as relationships between parameter estimates and gravitationally dependent position and lung inflation state. This provides a tool for probing physiologic processes that may be relevant to pulmonary disease and progression in newborns. Methods R2* and tissue density were estimated in a phantom consisting of standards allowing for ground truth comparisons and in human subjects (N = 5 infants, N = 4 adults, no clinical indication of lung dysfunction) using a 3D radial multiecho ultrashort echo time MRI sequence. Whole lung averages were compared between infants and adults. Dependence of the metrics on anterior-posterior position as well as between end-tidal inspiration and expiration were explored, in addition to the general relationship between R2* and tissue density. Results Estimates in the phantom did not differ significantly from ground truth. Neonates had significantly lower mean R2* (P = .006) and higher mean tissue density (P = 1.5e-5) than adults. Tissue density and R2* were both significantly dependent on anterior-posterior position and lung inflation state (P < .005). An overall inverse relationship was found between R2* and tissue density, which was similar in both neonates and adults. Conclusion Estimation of tissue density and R2* in free breathing, nonsedated, neonatal patients is feasible using multiecho ultrashort echo time MRI. R2* was no different between infants and adults when matched for tissue density, although density of lung parenchyma was, on average, lower in adults than neonates.
Details
- Title: Subtitle
- Characterization of R2and tissue density in the human lung: Application to neonatal imaging in the intensive care unit
- Creators
- Andrew D. Hahn - University of Wisconsin–MadisonAnnelise Malkus - University of Wisconsin–MadisonJeffery Kammerman - University of Wisconsin–MadisonNara Higano - Cincinnati Children's Hospital Medical CenterLaura Walkup - Cincinnati Children's Hospital Medical CenterJason Woods - Cincinnati Children's Hospital Medical CenterSean B. Fain - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medicine, Vol.84(2), pp.920-927
- DOI
- 10.1002/mrm.28137
- PMID
- 31855294
- PMCID
- PMC7180096
- NLM abbreviation
- Magn Reson Med
- ISSN
- 0740-3194
- eISSN
- 1522-2594
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- T32 HL0007752; T32 CA009206 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01 HL126771; R01 HL146689 / NIH/NHLBI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 08/01/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984275057702771
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