Characterization of Staphylococcus aureus Enterotoxin L

Paul M Orwin; J. Ross Fitzgerald; Donald Y. M Leung; Juan A Gutierrez; Gregory A Bohach; Patrick M Schlievert

doi:10.1128/IAI.71.5.2916-2919.2003

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Characterization of Staphylococcus aureus Enterotoxin L

Journal article

Open access

Peer reviewed

Characterization of Staphylococcus aureus Enterotoxin L

Paul M Orwin, J. Ross Fitzgerald, Donald Y. M Leung, Juan A Gutierrez, Gregory A Bohach and Patrick M Schlievert

Infection and immunity, Vol.71(5), pp.2916-2919

05/2003

DOI: 10.1128/IAI.71.5.2916-2919.2003

PMCID: PMC153286

PMID: 12704169

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Abstract

Staphylococcus aureus causes a wide variety of diseases. Major virulence factors of this organism include enterotoxins (SEs) that cause both food poisoning and toxic shock syndrome. Recently, a novel SE, tentatively designated SEL, was identified in a pathogenicity island from a bovine mastitis isolate. The toxin had a molecular weight of 26,000 and an isoelectric point of 8.5. Recombinant SEL shared many biological activities with SEs, including superantigenicity, pyrogenicity, enhancement of endotoxin shock, and lethality in rabbits when administered in subcutaneous miniosmotic pumps, but the protein lacked emetic activity. T cells bearing the T-cell receptor β chain variable regions 5.1, 5.2, 6.7, 16, and 22 were significantly stimulated by recombinant SEL.

Molecular Pathogenesis

Details

Title: Subtitle: Characterization of Staphylococcus aureus Enterotoxin L
Creators: Paul M Orwin - Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, Idaho 83844
J. Ross Fitzgerald - Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, Idaho 83844
Donald Y. M Leung - Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, Idaho 83844
Juan A Gutierrez - Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, Idaho 83844
Gregory A Bohach - Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, Idaho 83844
Patrick M Schlievert - Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, Idaho 83844
Resource Type: Journal article
Publication Details: Infection and immunity, Vol.71(5), pp.2916-2919
DOI: 10.1128/IAI.71.5.2916-2919.2003
PMID: 12704169
PMCID: PMC153286
NLM abbreviation: Infect Immun
ISSN: 0019-9567
eISSN: 1098-5522
Publisher: American Society for Microbiology
Language: English
Date published: 05/2003
Academic Unit: Microbiology and Immunology; Internal Medicine
Record Identifier: 9984001160002771

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