Journal article
Characterization of V36C, a Novel Amino Acid Substitution Conferring Hepatitis C Virus (HCV) Resistance to Telaprevir, a Potent Peptidomimetic Inhibitor of HCV Protease
Antimicrobial agents and chemotherapy, Vol.54(6), pp.2681-2683
06/2010
DOI: 10.1128/AAC.01796-09
PMCID: PMC2876365
PMID: 20368394
Abstract
We characterized a novel substitution conferring moderate resistance to telaprevir, a peptidomimetic inhibitor of hepatitis C virus protease. V36C conferred a 4.0-fold increase in the telaprevir 50% inhibitory concentration in an enzyme assay and a 9.5-fold increase in the replicon model. The replication capacity of a replicon harboring V36C was close to that of the wild-type protease. This case emphasizes the complexity of hepatitis C virus resistance to protease inhibitors.
Details
- Title: Subtitle
- Characterization of V36C, a Novel Amino Acid Substitution Conferring Hepatitis C Virus (HCV) Resistance to Telaprevir, a Potent Peptidomimetic Inhibitor of HCV Protease
- Creators
- Laetitia Barbotte - Department of VirologyAbdelhakim Ahmed-Belkacem - InsermStéphane Chevaliez - InsermAlexandre Soulier - InsermChristophe Hézode - InsermHenri Wajcman - InsermDoug J Bartels - Vertex PharmaceuticalsYi Zhou - Vertex PharmaceuticalsAndrzej Ardzinski - Vertex PharmaceuticalsNagraj Mani - Vertex PharmaceuticalsB. Govinda Rao - Vertex PharmaceuticalsShelley George - Vertex PharmaceuticalsAnn Kwong - Vertex PharmaceuticalsJean-Michel Pawlotsky - Inserm
- Resource Type
- Journal article
- Publication Details
- Antimicrobial agents and chemotherapy, Vol.54(6), pp.2681-2683
- Publisher
- American Society for Microbiology
- DOI
- 10.1128/AAC.01796-09
- PMID
- 20368394
- PMCID
- PMC2876365
- ISSN
- 0066-4804
- eISSN
- 1098-6596
- Language
- English
- Date published
- 06/2010
- Academic Unit
- Anatomy and Cell Biology
- Record Identifier
- 9984284346302771
Metrics
8 Record Views