Journal article
Characterization of an acquired IgG inhibitor of coagulation factor XIII in a patient with systemic lupus erythematosus
British journal of haematology, Vol.93(3), pp.700-703
06/1996
DOI: 10.1046/j.1365-2141.1996.d01-1678.x
PMID: 8652397
Abstract
An acquired IgG inhibitor to factor XIII was identified in a 30‐year‐old Vietnamese woman with systemic lupus erythematosus. The IgG fraction was isolated from plasma by chromatography on an agarose gel column and by protein G adsorption. The anti‐factor XIII activity, identified within the IgG fraction, inhibited factor XIII from both normal plasma (a2b2) and platelets (a2). A normal level of the b subunit was measured by immunoelectrophoresis of the patient’s plasma, but the a subunit was not detected. These results suggested the presence of an IgG immunoglobulin which recognized the a subunit and interfered with its activity.
Details
- Title: Subtitle
- Characterization of an acquired IgG inhibitor of coagulation factor XIII in a patient with systemic lupus erythematosus
- Creators
- Ferhaan AhmadSusan SolymossMan‐Chiu PoonCaroline BerubeArthur K Sullivan
- Resource Type
- Journal article
- Publication Details
- British journal of haematology, Vol.93(3), pp.700-703
- Publisher
- Blackwell Science Ltd; Oxford, U.K. and Cambridge, USA
- DOI
- 10.1046/j.1365-2141.1996.d01-1678.x
- PMID
- 8652397
- ISSN
- 0007-1048
- eISSN
- 1365-2141
- Number of pages
- 4
- Language
- English
- Date published
- 06/1996
- Academic Unit
- Radiology; Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025687402771
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