Journal article
Characterization of an enterovirus associated with acute infectious lymphocytosis
Journal of general virology, Vol.30(3), pp.347-355
03/1976
DOI: 10.1099/0022-1317-30-3-347
PMID: 176314
Abstract
An enterovirus (EVU-16) previously isolated from children with acute infectious lymphocytosis has been further characterized. The EVU-16 virus sediments as a 135S particle in sucrose gradients, has a density of 1-335 g/ml in CsCl, contains 4 polypeptides and has a single stranded RNA genome sedimenting at 35S. These structural features as well as the presence of a virus-related particle, the procapsid, are similar to those of other enteroviruses. However, the largest polypeptide of EVU-16 is 49000 daltons, which is considerably larger than the corresponding polypeptide from poliovirus; the sizes of the other three viral polypeptides were similar in both viruses. Attempts to induce lymphocytosis by the inoculation of EVU-16 into various animals, including immunologically aberrant 'nude' mice, were unsuccessful.
Details
- Title: Subtitle
- Characterization of an enterovirus associated with acute infectious lymphocytosis
- Creators
- C GroseM S Horwitz
- Resource Type
- Journal article
- Publication Details
- Journal of general virology, Vol.30(3), pp.347-355
- DOI
- 10.1099/0022-1317-30-3-347
- PMID
- 176314
- ISSN
- 0022-1317
- eISSN
- 1465-2099
- Language
- English
- Date published
- 03/1976
- Academic Unit
- Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984093342502771
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