Journal article
Characterization of bleeding symptoms in Ehlers-Danlos syndrome
Journal of thrombosis and haemostasis, Vol.21(7), pp.1824-1830
07/01/2023
DOI: 10.1016/j.jtha.2023.04.004
PMID: 37179130
Abstract
Background: Easy bruising is included as a major or minor criterion for the classification of multiple types of Ehlers-Danlos syndrome (EDS). Despite a longstanding recognition of the association between EDS and bleeding, we still lack a definitive understanding of the frequency, severity, and types of bleeding complications in patients with EDS.Objectives: To evaluate hemorrhagic symptoms using the International Society of Thrombosis and Haemostasis bleeding assessment tool (ISTH-BAT) in a cohort of patients with defined types of EDS.Methods: We utilized the ISTH-BAT to characterize hemorrhagic symptoms and their severity in a cohort of 52 patients with classical, classical-like, hypermobile, or vascular EDS and a matched group of 52 healthy control subjects.Results: The mean ISTH-BAT score was 0.1 for healthy subjects and 9.1 for patients with EDS (p < .0001). An abnormal ISTH-BAT score was observed in 32 of 52 (62%) patients with EDS and 0 of 52 healthy controls (p < .0001). The most frequent bleeding symptoms were bruising, muscle hematomas, menorrhagia, epistaxis, bleeding from the oral cavity, and bleeding after tooth extraction. Menorrhagia that was life-threatening or required surgery was reported in 7 of 52 (14%) patients with EDS.Conclusion: Patients with multiple types of EDS exhibit a wide range of bleeding symptoms ranging from mild to life-threatening episodes.
Details
- Title: Subtitle
- Characterization of bleeding symptoms in Ehlers-Danlos syndrome
- Creators
- Mariia Kumskova - University of IowaGagan D. Flora - University of IowaJanice Staber - University of IowaSteven R. Lentz - University of IowaAnil K. Chauhan - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of thrombosis and haemostasis, Vol.21(7), pp.1824-1830
- DOI
- 10.1016/j.jtha.2023.04.004
- PMID
- 37179130
- NLM abbreviation
- J Thromb Haemost
- ISSN
- 1538-7933
- eISSN
- 1538-7836
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- AHA Established Investigator Award; American Heart Association Innovative Investigator Research Award (National Hemophilia Foundation) R35HL139926; R01NS109910 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 07/01/2023
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Hematology/Oncology; Internal Medicine
- Record Identifier
- 9984949192902771
Metrics
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