Journal article
Characterization of drug delivery particles produced by supercritical carbon dioxide technologies
The Journal of supercritical fluids, Vol.128, pp.244-262
10/01/2017
DOI: 10.1016/j.supflu.2017.06.002
Abstract
[Display omitted]
•Review of characterization techniques for supercritical CO2 produced drug particles.•Inclusion of techniques to assess physical, chemical and biological properties.•Inclusion of techniques for pharmaceutically relevant scCO2-engineered particles.•Illustrative examples of relevant applications of the described techniques.
This review focuses on characterization methods for drug/excipient particles produced with supercritical CO2 (scCO2) particle engineering technologies. Proper characterization of particles can guide optimization of their production process and provide an indication of their in vivo behavior. In particular, characterization techniques for particle size distribution and morphology, drug loading and release, structure of matrix components, potency, porosity, particle surface chemistry, surface charge, biocompatibility and residual solvents are discussed. Moreover, we discuss particle analytical techniques that are not commonly used in the scCO2 research field but are of potential use for pharmaceutically relevant scCO2-engineered particles. These techniques often work synergistically in particle characterization by mutually supporting the interpretation of their outcomes, which is crucial to efficiently develop a successful production process of drug/excipient particles.
Details
- Title: Subtitle
- Characterization of drug delivery particles produced by supercritical carbon dioxide technologies
- Creators
- Onanong Nuchuchua - Centre for Human Drug ResearchM. Reza Nejadnik - Centre for Human Drug ResearchSebastiaan C. Goulooze - Centre for Human Drug ResearchNataša Jovanović Lješković - Pharmo InstituteHayley A. Every - FeyeCon (Netherlands)Wim Jiskoot - Centre for Human Drug Research
- Resource Type
- Journal article
- Publication Details
- The Journal of supercritical fluids, Vol.128, pp.244-262
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.supflu.2017.06.002
- ISSN
- 0896-8446
- eISSN
- 1872-8162
- Language
- English
- Date published
- 10/01/2017
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984420936802771
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