Journal article
Characterization of extended spectrum β-lactamase-producing Klebsiella pneumoniae from Beijing, China
International journal of antimicrobial agents, Vol.18(2), pp.185-188
2001
DOI: 10.1016/S0924-8579(01)00351-X
PMID: 11516943
Abstract
Fourteen clinical isolates of
Klebsiella pneumoniae with extended-spectrum β-lactamases (ESBLs) were detected by the double disk synergy test and the Etest ESBL strip. Co-resistances included high MICs for aminoglycosides, fluoroquinolones, tetracyclines, and trimethoprim/sulphamethoxazole. Co-resistance was not observed in five of the 14 strains. These isolates were all genetically distinct as determined by the automated ribotyping method. Isoelectric focusing documented the presence of multiple β-lactamases (one to four per isolate) with pIs ranging from 5.4 to 8.4. The majority of isolates contained β-lactamases with pI values of 7.6 and 8.4 consistent with SHV-type ESBLs and an Amp C enzyme, respectively. Emerging ESBL strains in
K. pneumoniae compromise the use of agents such as cefotaxime, ceftriaxone, ceftazidime in China; leading to the expansion of quality infection control practices and formulary management programmes to minimize clonal expansion.
Details
- Title: Subtitle
- Characterization of extended spectrum β-lactamase-producing Klebsiella pneumoniae from Beijing, China
- Creators
- Dingxia Shen - Department of Microbiology 301 Hospital 28, FuXing Road, Beijing 100853, People's Republic of ChinaPatricia Winokur - University of Iowa College of Medicine, Iowa City, IA, USARonald N Jones - University of Iowa College of Medicine, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- International journal of antimicrobial agents, Vol.18(2), pp.185-188
- DOI
- 10.1016/S0924-8579(01)00351-X
- PMID
- 11516943
- NLM abbreviation
- Int J Antimicrob Agents
- ISSN
- 0924-8579
- eISSN
- 1872-7913
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 2001
- Academic Unit
- Infectious Diseases; Medicine Administration; Internal Medicine
- Record Identifier
- 9984094748602771
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