Characterization of inhalable endotoxin, glucan, and dust exposures in Iowa farmers

Jean-François Sauvé; Sarah J Locke; Pabitra R Josse; Emma M Stapleton; Nervana Metwali; Ralph W Altmaier; Gabriella Andreotti; Peter S Thorne; Jonathan N Hofmann; Laura E Beane Freeman; Melissa C Friesen

doi:10.1016/j.ijheh.2020.113525

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Characterization of inhalable endotoxin, glucan, and dust exposures in Iowa farmers

Journal article

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Characterization of inhalable endotoxin, glucan, and dust exposures in Iowa farmers

Jean-François Sauvé, Sarah J Locke, Pabitra R Josse, Emma M Stapleton, Nervana Metwali, Ralph W Altmaier, Gabriella Andreotti, Peter S Thorne, Jonathan N Hofmann, Laura E Beane Freeman, …

International journal of hygiene and environmental health, Vol.228, pp.113525-113525

07/2020

DOI: 10.1016/j.ijheh.2020.113525

PMID: 32311660

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https://www.ncbi.nlm.nih.gov/pmc/articles/8010939View

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Abstract

The observed deficit of lung cancer in farmers has been partly attributed to exposure to organic dusts and endotoxins based largely on surrogate metrics. To move beyond these surrogates for etiological studies, we characterized task-based and time-weighted average (TWA) exposure to inhalable endotoxin, (1 → 3)-β-D-glucan, and dust in Iowa farmers. We collected 320 personal inhalable dust samples from 32 farmers during 69 sample days in 2015 and 2016. Samples were collected using Button aerosol samplers and analyzed for endotoxin using a kinetic chromogenic amebocyte lysate assay, and for (1 → 3)-β-D-glucan using a Limulus endpoint assay. We assessed relationships between bioaerosol concentrations and selected tasks and farm characteristics using linear mixed-effects models. Bedding work, hog handling, and working in barn/confinement buildings, grain bins, and grain elevators were associated with higher endotoxin exposure. We found a monotonic trend between higher endotoxin concentrations and increasing number of animals. Bedding work, cleaning, and feed/grain storage work were associated with higher (1 → 3)-β-D-glucan concentrations. The median concentrations by task spanned one order of magnitude for inhalable dust and two orders of magnitude for endotoxin and (1 → 3)-β-D-glucan. Pearson correlations between endotoxin and glucan concentrations were 0.22 for TWA exposure and 0.56 for task samples. This characterization of exposure factors that influence bioaerosol concentrations can support the development of refined bioaerosol exposure metrics for future etiologic analyses of cancer and other health outcomes in farmers.

Glucan

Agriculture

Occupational exposure

Endotoxin

Bioaerosols

Details

Title: Subtitle: Characterization of inhalable endotoxin, glucan, and dust exposures in Iowa farmers
Creators: Jean-François Sauvé - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States
Sarah J Locke - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States
Pabitra R Josse - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States
Emma M Stapleton - Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, United States
Nervana Metwali - Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, United States
Ralph W Altmaier - Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, United States
Gabriella Andreotti - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States
Peter S Thorne - Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, United States
Jonathan N Hofmann - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States
Laura E Beane Freeman - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States
Melissa C Friesen - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States
Resource Type: Journal article
Publication Details: International journal of hygiene and environmental health, Vol.228, pp.113525-113525
DOI: 10.1016/j.ijheh.2020.113525
PMID: 32311660
NLM abbreviation: Int J Hyg Environ Health
ISSN: 1438-4639
eISSN: 1618-131X
Publisher: Elsevier GmbH
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000054, name: National Cancer Institute; DOI: 10.13039/100000066, name: National Institute of Environmental Health Sciences, award: NIH P30 ES005605
Language: English
Date published: 07/2020
Academic Unit: Civil and Environmental Engineering; Occupational and Environmental Health; Internal Medicine
Record Identifier: 9984000918302771

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