Characterization of large structural genetic mosaicism in human autosomes

Brian E Henderson; Keitaro Matsuo; Mitchell J Machiela; Kexin Chen; Yun-Chul Hong; Weiyin Zhou; Sara H Olson; Veronica Wendy Setiawan; H Dean Hosgood III; Joshua N Sampson; Irene Orlow; Hongbing Shen; Chao A Hsiung; Michael C Dean; Jae Yong Park; Linda S Cook; Wei Hu; Kevin B Jacobs; Loreall Pooler; Marta Crous Bou; David J Hunter; Jennifer Prescott; Amanda Black; Xin Sheng; Lea Jessop; Immaculata De Vivo; Louise A Brinton; Radhai Rastogi; Hee Nam Kim; I-Shou Chang; Harvey A Risch; Min-Ho Shin; Fredrick Schumacher; Yeul Hong Kim; Jennifer Doherty; Chu Chen; Young Tae Kim; Adeline Seow; Xiao-Ou Shu; Constance Chen; Christine M Friedenreich; Robert Klein; Peter Kraft; David VanDen Berg; Qing Lan; Mia M Gaudet; Jiu-Cun Wang; Dongxin Lin; Jianjun Liu; Christopher A Haiman; Loic Le Marchand; Nicolas Wentzensen; Xiaolin Liang; Susan E Hankinson; Jolanta Lissowska; Maria Pik Wong; Lingeng Lu; Chen Wu; Anthony M Magliocco; Patricia Hartge; Tangchun Wu; Yi-Long Wu; Lucy Xia; Hannah P Yang; Pan-Chyr Yang; Wei Zheng; Baosen Zhou; Christian C Abnet; Demetrius Albanes; Melinda C Aldrich; Christopher Amos; Laufey T Amundadottir; Sonja I Berndt; William J Blot; Cathryn H Bock; Paige M Bracci; Laurie Burdett; Julie E Buring; Mary A Butler; Tania Carreón; Nilanjan Chatterjee; Charles C Chung; Michael B Cook; Michael Cullen; Faith G Davis; Ti Ding; Eric J Duell; Caroline G Epstein; Jin-Hu Fan; Jonine D Figueroa; Joseph F Fraumeni Jr; Neal D Freedman; Charles S Fuchs; Yu-Tang Gao; Susan M Gapstur; Ana Patiño-Garcia; Montserrat Garcia-Closas; J Michael Gaziano; Graham G Giles; Elizabeth M Gillanders; Edward L Giovannucci; Lynn Goldin; Alisa M Goldstein; Mark H Greene; Goran Hallmans; Curtis C Harris; Roger Henriksson; Elizabeth A Holly; Robert N Hoover; Nan Hu; Amy Hutchinson; Mazda Jenab; Christoffer Johansen; Kay-Tee Khaw; Woon-Puay Koh; Laurence N Kolonel; Charles Kooperberg; Vittorio Krogh; Robert C Kurtz; Andrea LaCroix; Annelie Landgren; Maria Teresa Landi; Donghui Li; Linda M Liao; Nuria Malats; Katherine A McGlynn; Lorna H McNeill; Robert R McWilliams; Beatrice S Melin; Lisa Mirabello; Beata Peplonska; Ulrike Peters; Gloria M Petersen; Ludmila Prokunina-Olsson; Mark Purdue; You-Lin Qiao; Kari G Rabe; Preetha Rajaraman; Francisco X Real; Elio Riboli; Benjamín Rodríguez-Santiago; Nathaniel Rothman; Avima M Ruder; Sharon A Savage; Ann G Schwartz; Kendra L Schwartz; Howard D Sesso; Gianluca Severi; Debra T Silverman; Margaret R Spitz; Victoria L Stevens; Rachael Stolzenberg-Solomon; Daniel Stram; Ze-Zhong Tang; Philip R Taylor; Lauren R Teras; Geoffrey S Tobias; Kala Viswanathan; Sholom Wacholder; Zhaoming Wang; Stephanie J Weinstein; William Wheeler; Emily White; John K Wiencke; Brian M Wolpin; Xifeng Wu; Jay S Wunder; Kai Yu; Krista A Zanetti; Anne Zeleniuch-Jacquotte; Regina G Ziegler; Mariza de Andrade; Kathleen C Barnes; Terri H Beaty; Laura J Bierut; Karl C Desch; Kimberly F Doheny; Bjarke Feenstra; David Ginsburg; John A Heit; Jae H Kang; Cecilia A Laurie; Jun Z Li; William L Lowe; Mary L Marazita; Mads Melbye; Daniel B Mirel; Jeffrey C Murray; Sarah C Nelson; Louis R Pasquale; Kenneth Rice; Janey L Wiggs; Anastasia Wise; Margaret Tucker; Luis A Pérez-Jurado; Cathy C Laurie; Neil E Caporaso; Meredith Yeager; Stephen J Chanock

doi:10.1016/j.ajhg.2015.01.011

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Characterization of large structural genetic mosaicism in human autosomes

Journal article

Open access

Peer reviewed

Characterization of large structural genetic mosaicism in human autosomes

Brian E Henderson, Keitaro Matsuo, Mitchell J Machiela, Kexin Chen, Yun-Chul Hong, Weiyin Zhou, Sara H Olson, Veronica Wendy Setiawan, H Dean Hosgood III, Joshua N Sampson, …

American journal of human genetics, Vol.96(3), pp.487-497

03/05/2015

DOI: 10.1016/j.ajhg.2015.01.011

PMCID: PMC4375431

PMID: 25748358

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https://doi.org/10.1016/j.ajhg.2015.01.011View

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Abstract

Analyses of genome-wide association study (GWAS) data have revealed that detectable genetic mosaicism involving large (>2 Mb) structural autosomal alterations occurs in a fraction of individuals. We present results for a set of 24,849 genotyped individuals (total GWAS set II [TGSII]) in whom 341 large autosomal abnormalities were observed in 168 (0.68%) individuals. Merging data from the new TGSII set with data from two prior reports (the Gene-Environment Association Studies and the total GWAS set I) generated a large dataset of 127,179 individuals; we then conducted a meta-analysis to investigate the patterns of detectable autosomal mosaicism (n = 1,315 events in 925 [0.73%] individuals). Restricting to events >2 Mb in size, we observed an increase in event frequency as event size decreased. The combined results underscore that the rate of detectable mosaicism increases with age (p value = 5.5 × 10(-31)) and is higher in men (p value = 0.002) but lower in participants of African ancestry (p value = 0.003). In a subset of 47 individuals from whom serial samples were collected up to 6 years apart, complex changes were noted over time and showed an overall increase in the proportion of mosaic cells as age increased. Our large combined sample allowed for a unique ability to characterize detectable genetic mosaicism involving large structural events and strengthens the emerging evidence of non-random erosion of the genome in the aging population.

Genome-Wide Association Study

Neoplasms - genetics

Humans

Middle Aged

Chromosome Aberrations

Female

Genotype

Male

Mosaicism

Aged

Genome, Human

Details

Title: Subtitle: Characterization of large structural genetic mosaicism in human autosomes
Creators: Brian E Henderson - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Keitaro Matsuo - Department of Preventive Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka 819-0395, Japan
Mitchell J Machiela - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Kexin Chen - Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300040, People's Republic of China
Yun-Chul Hong - Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul 151-742, Republic of Korea
Weiyin Zhou - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Leidos Biomedical Research Inc., Bethesda, MD 20892, USA
Sara H Olson - Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Veronica Wendy Setiawan - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
H Dean Hosgood III - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Joshua N Sampson - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Irene Orlow - Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Hongbing Shen - Jiangsu Key Laboratory of Cancer Biomarkers, Prevention, and Treatment, Nanjing Medical University, Nanjing 210029, People's Republic of China; Ministry of Education Key Laboratory of Modern Toxicology, Nanjing Medical University, Nanjing 210029, People's Republic of China
Chao A Hsiung - Institute of Population Health Sciences, National Health Research Institutes, Zhunan 35053, Taiwan, ROC
Michael C Dean - Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, MD 21702, USA
Jae Yong Park - Lung Cancer Center, Kyungpook National University Medical Center, Daegu 101, Republic of Korea
Linda S Cook - University of New Mexico, Albuquerque, NM 87131, USA
Wei Hu - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Kevin B Jacobs - Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Leidos Biomedical Research Inc., Bethesda, MD 20892, USA; BioInformed LLC, Gaithersburg, MD 20877, USA
Loreall Pooler - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90007, USA
Marta Crous Bou - Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
David J Hunter - Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
Jennifer Prescott - Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
Amanda Black - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Xin Sheng - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90007, USA
Lea Jessop - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Immaculata De Vivo - Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
Louise A Brinton - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Radhai Rastogi - Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Hee Nam Kim - Center for Creative Biomedical Scientists, Chonnam National University, Gwangju 500-757, Republic of Korea
I-Shou Chang - National Institute of Cancer Research, National Health Research Institutes, Zhunan 35053, Taiwan, ROC
Harvey A Risch - Yale School of Public Health, New Haven, CT 06510, USA
Min-Ho Shin - Department of Preventive Medicine, Chonnam National University Medical School, Gwanju 501-746, Republic of Korea
Fredrick Schumacher - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Yeul Hong Kim - Division of Oncology/Hematology, Department of Internal Medicine, College of Medicine, Korea University Anam Hospital, Seoul 151-742, Republic of Korea
Jennifer Doherty - Geisel School of Medicine, Dartmouth College, Lebanon, NH 03755, USA
Chu Chen - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Young Tae Kim - Department of Thoracic and Cardiovascular Surgery, Cancer Research Institute, College of Medicine, Seoul National University, Seoul 151-742, Republic of Korea
Adeline Seow - Saw Swee Hock School of Public Health, National University of Singapore, Singapore 119077, Singapore
Xiao-Ou Shu - Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Constance Chen - Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA 02115, USA
Christine M Friedenreich - Department of Population Health Research, CancerControl Alberta, Alberta Health Services, Calgary, AB T2N 2T9, Canada
Robert Klein - Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Peter Kraft - Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA 02115, USA
David VanDen Berg - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Qing Lan - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Mia M Gaudet - Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA
Jiu-Cun Wang - Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433, People's Republic of China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, People's Republic of China
Dongxin Lin - Department of Etiology & Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, People's Republic of China; State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, People's Republic of China
Jianjun Liu - Department of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore; School of Life Sciences, Anhui Medical University, Hefei 230032, People's Republic of China
Christopher A Haiman - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Loic Le Marchand - Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA
Nicolas Wentzensen - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Xiaolin Liang - Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Susan E Hankinson - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA
Jolanta Lissowska - Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw 02-781, Poland
Maria Pik Wong - Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, People's Republic of China
Lingeng Lu - Yale School of Public Health, New Haven, CT 06510, USA
Chen Wu - Department of Etiology & Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, People's Republic of China; State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, People's Republic of China
Anthony M Magliocco - H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Patricia Hartge - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Tangchun Wu - Institute of Occupational Medicine and Ministry of Education Key Laboratory for Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan 430400, People's Republic of China
Yi-Long Wu - Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou 515200, People's Republic of China
Lucy Xia - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90007, USA
Hannah P Yang - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Pan-Chyr Yang - Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei 10617, Taiwan, ROC
Wei Zheng - Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Baosen Zhou - Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110001, People's Republic of China
Christian C Abnet - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Demetrius Albanes - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Melinda C Aldrich - Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Thoracic Surgery, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA
Christopher Amos - Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Laufey T Amundadottir - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Sonja I Berndt - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
William J Blot - Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; International Epidemiology Institute, Rockville, MD 20850, USA
Cathryn H Bock - Karmanos Cancer Institute and Department of Oncology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
Paige M Bracci - Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94143, USA
Laurie Burdett - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Leidos Biomedical Research Inc., Bethesda, MD 20892, USA
Julie E Buring - Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA
Mary A Butler - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA
Tania Carreón - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA
Nilanjan Chatterjee - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Charles C Chung - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Leidos Biomedical Research Inc., Bethesda, MD 20892, USA
Michael B Cook - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Michael Cullen - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Leidos Biomedical Research Inc., Bethesda, MD 20892, USA
Faith G Davis - Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, AB T6G 2R3, Canada
Ti Ding - Shanxi Cancer Hospital, Taiyuan, Shanxi 030013, People's Republic of China
Eric J Duell - Unit of Nutrition, Environment, and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute,, Barcelona 08908, Spain
Caroline G Epstein - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Jin-Hu Fan - Shanghai Cancer Institute, Shanghai 200032, People's Republic of China
Jonine D Figueroa - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Joseph F Fraumeni Jr - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Neal D Freedman - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Charles S Fuchs - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Yu-Tang Gao - Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiaotaong University Shanghai 200032, People's Republic of China
Susan M Gapstur - Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA
Ana Patiño-Garcia - Department of Pediatrics, University Clinic of Navarra, Universidad de Navarra, Pamplona 31080, Spain
Montserrat Garcia-Closas - Division of Genetics and Epidemiology and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, Surrey SM2 5NG, UK
J Michael Gaziano - Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Massachusetts Veterans Epidemiology Research and Information Center and Cooperative Studies Programs, Veterans Affairs Boston Healthcare System, Boston, MA 02130, USA
Graham G Giles - Cancer Epidemiology Centre, Cancer Council Victoria and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia
Elizabeth M Gillanders - Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Edward L Giovannucci - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Lynn Goldin - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Alisa M Goldstein - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Mark H Greene - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Goran Hallmans - Nutritional Research Unit, Department of Public Health and Clinical Medicine, Umeå University, Umeå 901 87, Sweden
Curtis C Harris - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Roger Henriksson - Department of Oncology, Department of Radiation Sciences, Umeå University, Umeå 901 87, Sweden
Elizabeth A Holly - Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94143, USA
Robert N Hoover - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Nan Hu - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Amy Hutchinson - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Leidos Biomedical Research Inc., Bethesda, MD 20892, USA
Mazda Jenab - International Agency for Research on Cancer, Lyon 69372, France
Christoffer Johansen - Department of Oncology, Finsen Centre, Rigshospitalet, Copenhagen 2100, Denmark; Unit of Survivorship Research, Danish Cancer Society Research Centre, Copenhagen 2100, Denmark
Kay-Tee Khaw - School of Clinical Medicine, University of Cambridge, Cambridge CB2 1TN, UK
Woon-Puay Koh - Saw Swee Hock School of Public Health, National University of Singapore, Singapore 119077, Singapore; Duke-NUS Graduate Medical School, Singapore 169857, Singapore
Laurence N Kolonel - Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA
Charles Kooperberg - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Vittorio Krogh - Fondazione IRCCS Istituto Nazionale dei Tumori, Milano 20133, Italy
Robert C Kurtz - Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Andrea LaCroix - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Annelie Landgren - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Maria Teresa Landi - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Donghui Li - Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Linda M Liao - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Nuria Malats - Spanish National Cancer Research Centre, Madrid 28029, Spain
Katherine A McGlynn - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Lorna H McNeill - Department of Health Disparities Research, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for Community-Engaged Translational Research, Duncan Family Institute, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Robert R McWilliams - Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA
Beatrice S Melin - Department of Oncology, Department of Radiation Sciences, Umeå University, Umeå 901 87, Sweden
Lisa Mirabello - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Beata Peplonska - Nofer Institute of Occupational Medicine, Lodz 91-348, Poland
Ulrike Peters - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Gloria M Petersen - Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
Ludmila Prokunina-Olsson - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Mark Purdue - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
You-Lin Qiao - Department of Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100730, People's Republic of China
Kari G Rabe - Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
Preetha Rajaraman - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Francisco X Real - Spanish National Cancer Research Centre, Madrid 28029, Spain; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain
Elio Riboli - Division of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London SW7 2AZ, UK
Benjamín Rodríguez-Santiago - Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras, Barcelona 08003, Spain; Quantitative Genomic Medicine Laboratory, qGenomics, Barcelona 08003, Spain
Nathaniel Rothman - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Avima M Ruder - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA
Sharon A Savage - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Ann G Schwartz - Karmanos Cancer Institute and Department of Oncology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
Kendra L Schwartz - Karmanos Cancer Institute and Department of Family Medicine and Public Health Sciences, School of Medicine, Wayne State University, Detroit, MI 48201, USA
Howard D Sesso - Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA
Gianluca Severi - Cancer Epidemiology Centre, Cancer Council Victoria and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia; Human Genetics Foundation, Torino 10126, Italy
Debra T Silverman - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Margaret R Spitz - Baylor College of Medicine, Houston, TX 77030, USA
Victoria L Stevens - Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA
Rachael Stolzenberg-Solomon - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Daniel Stram - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Ze-Zhong Tang - Shanxi Cancer Hospital, Taiyuan, Shanxi 030013, People's Republic of China
Philip R Taylor - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Lauren R Teras - Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA
Geoffrey S Tobias - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Kala Viswanathan - Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21218, USA
Sholom Wacholder - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Zhaoming Wang - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Leidos Biomedical Research Inc., Bethesda, MD 20892, USA
Stephanie J Weinstein - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
William Wheeler - Information Management Services Inc., Calverton, MD 20904, USA
Emily White - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
John K Wiencke - University of California, San Francisco, San Francisco, CA 94143, USA
Brian M Wolpin - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Xifeng Wu - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Jay S Wunder - Division of Urologic Surgery, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA
Kai Yu - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Krista A Zanetti - Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Anne Zeleniuch-Jacquotte - Department of Population Health, School of Medicine, New York University, New York, NY 10016, USA; Perlmutter Cancer Institute, New York University, New York, NY 10016, USA
Regina G Ziegler - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Mariza de Andrade - Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
Kathleen C Barnes - School of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA
Terri H Beaty - Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21218, USA
Laura J Bierut - Department of Psychiatry, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA
Karl C Desch - Department of Pediatrics and Communicable Diseases, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI 48109, USA
Kimberly F Doheny - Center for Inherited Disease Research, Institute of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA
Bjarke Feenstra - Department of Epidemiology Research, Statens Serum Institut, Copenhagen 2300, Denmark
David Ginsburg - Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
John A Heit - Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
Jae H Kang - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
Cecilia A Laurie - Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
Jun Z Li - Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
William L Lowe - Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60208, USA
Mary L Marazita - Center for Craniofacial and Dental Genetics, Department of Oral Biology School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
Mads Melbye - Department of Epidemiology Research, Statens Serum Institut, Copenhagen 2300, Denmark; Department of Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA
Daniel B Mirel - Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
Jeffrey C Murray - Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
Sarah C Nelson - Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
Louis R Pasquale - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard University, Boston, MA 02114, USA
Kenneth Rice - Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
Janey L Wiggs - Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard University, Boston, MA 02114, USA
Anastasia Wise - Office of Population Genomics, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
Margaret Tucker - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Luis A Pérez-Jurado - Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras, Barcelona 08003, Spain; Hospital del Mar Research Institute, Barcelona 08003, Spain
Cathy C Laurie - Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
Neil E Caporaso - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Meredith Yeager - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Leidos Biomedical Research Inc., Bethesda, MD 20892, USA
Stephen J Chanock - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: chanocks@mail.nih.gov
Resource Type: Journal article
Publication Details: American journal of human genetics, Vol.96(3), pp.487-497
DOI: 10.1016/j.ajhg.2015.01.011
PMID: 25748358
PMCID: PMC4375431
NLM abbreviation: Am J Hum Genet
ISSN: 0002-9297
eISSN: 1537-6605
Publisher: United States
Grant note: R01 DE014899 / NIDCR NIH HHS G0401527 / Medical Research Council UM1 CA182910 / NCI NIH HHS P30 EY014104 / NEI NIH HHS R01 CA092447 / NCI NIH HHS K07 CA172294 / NCI NIH HHS R01 DE016148 / NIDCR NIH HHS UM1 CA182934 / NCI NIH HHS R25 CA174664 / NCI NIH HHS P30 CA023108 / NCI NIH HHS P01 CA087969 / NCI NIH HHS R01 CA124908 / NCI NIH HHS P30 CA008748 / NCI NIH HHS P50 CA102701 / NCI NIH HHS R01 EY022305 / NEI NIH HHS R01 EY015473 / NEI NIH HHS K05 CA154337 / NCI NIH HHS R01 HL039693 / NHLBI NIH HHS G1000143 / Medical Research Council R01 HL112642 / NHLBI NIH HHS
Language: English
Date published: 03/05/2015
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
Record Identifier: 9984025339802771

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