Journal article
Characterization of splenic CD21hi T2 B cells
Immunologic research, Vol.39(1), pp.240-248
11/2007
DOI: 10.1007/s12026-007-0072-5
PMID: 17917068
Abstract
B cell development is a highly regulated process that initiates in the bone marrow (BM) of adult mice. After reaching the IgM+ immature stage in the BM, these B cells migrate to the spleen to complete maturation and incorporation into the long-lived peripheral lymphocyte pool. Studies have identified these splenic immature B cells, and have further attempted to delineate the sequence whereby they transition into mature B cells. As such, these immature splenic populations are termed transitional B cells and have been the focus of intense study. The review summarizes the phenotype and currently known functions of the four putative transitional B cell subsets identified to date. Although most appear to represent short-lived transitional B cells, the CD21hi T2 B cell population exhibits a number of qualities that question its label as a transitional B cell subset.
Details
- Title: Subtitle
- Characterization of splenic CD21hi T2 B cells
- Creators
- Shilpi Verma - Interdisciplinary Graduate Program in Immunology University of Iowa Iowa City IA 52242 USAThomas Waldschmidt - 1038 Medical Laboratories University of Iowa Iowa City IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Immunologic research, Vol.39(1), pp.240-248
- Publisher
- Humana Press Inc; New York
- DOI
- 10.1007/s12026-007-0072-5
- PMID
- 17917068
- ISSN
- 0257-277X
- eISSN
- 1559-0755
- Language
- English
- Date published
- 11/2007
- Academic Unit
- Pathology
- Record Identifier
- 9984047644302771
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