Characterization of the Jet-Flow Overpressure Model of Traumatic Brain Injury in Mice

Min-Kyoo Shin; Edwin Vázquez-Rosa; Coral J Cintrón-Pérez; William A Riegel; Matthew M Harper; David Ritzel; Andrew A Pieper

doi:10.1089/neur.2020.0020

Back

Characterization of the Jet-Flow Overpressure Model of Traumatic Brain Injury in Mice

Journal article

Open access

Peer reviewed

Characterization of the Jet-Flow Overpressure Model of Traumatic Brain Injury in Mice

Min-Kyoo Shin, Edwin Vázquez-Rosa, Coral J Cintrón-Pérez, William A Riegel, Matthew M Harper, David Ritzel and Andrew A Pieper

Neurotrauma Reports, Vol.2(1), pp.1-13

01/01/2021

DOI: 10.1089/neur.2020.0020

PMID: 33748810

Files and links (1)

url

https://doi.org/10.1089/neur.2020.0020View

Published (Version of record) Open Access

Abstract

The jet-flow overpressure chamber (OPC) has been previously reported as a model of blast-mediated traumatic brain injury (bTBI). However, rigorous characterization of the features of this injury apparatus shows that it fails to recapitulate exposure to an isolated blast wave. Through combined experimental and computational modeling analysis of gas-dynamic flow conditions, we show here that the jet-flow OPC produces a collimated high-speed jet flow with extreme dynamic pressure that delivers a severe compressive impulse. Variable rupture dynamics of the diaphragm through which the jet flow originates also generate a weak and infrequent shock front. In addition, there is a component of acceleration-deceleration injury to the head as it is agitated in the headrest. Although not a faithful model of free-field blast exposure, the jet-flow OPC produces a complex multi-modal model of TBI that can be useful in laboratory investigation of putative TBI therapies and fundamental neurophysiological processes after brain injury.

multi-modal traumatic brain injury

jet flow

overpressure chamber

Original

blast

Details

Title: Subtitle: Characterization of the Jet-Flow Overpressure Model of Traumatic Brain Injury in Mice
Creators: Min-Kyoo Shin - Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA
Edwin Vázquez-Rosa - Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA
Coral J Cintrón-Pérez - Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA
William A Riegel - Stumptown Research and Development, LLC, Black Mountain, North Carolina, USA
Matthew M Harper - Center for the Prevention and Treatment of Visual Loss, Veterans Affairs Medical Center, Iowa City, Iowa, USA
David Ritzel - Dyn-FX Consulting, Ltd., Amherstburg, Ontario, Canada
Andrew A Pieper - Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA
Resource Type: Journal article
Publication Details: Neurotrauma Reports, Vol.2(1), pp.1-13
DOI: 10.1089/neur.2020.0020
PMID: 33748810
NLM abbreviation: Neurotrauma Rep
ISSN: 2689-288X
eISSN: 2689-288X
Publisher: Mary Ann Liebert, Inc., publishers
Alternative title: Shin et al.; Neurotrauma Reports 2021, 2.1
Language: English
Date published: 01/01/2021
Academic Unit: Psychiatry; Biology; Ophthalmology and Visual Sciences
Record Identifier: 9984101222902771

Metrics

18 Record Views

9 Times Cited - Web of Science