Journal article
Characterization of the Type 3 Fimbrial Adhesins of Klebsiella Strains
Infection and immunity, Vol.66(6), pp.2887-2894
06/1998
DOI: 10.1128/IAI.66.6.2887-2894.1998
PMCID: PMC108286
PMID: 9596764
Abstract
The
Klebsiella pneumoniae
fimbrial adhesin, MrkD, mediates adherence to the basolateral surfaces of renal and pulmonary epithelia and to the basement membranes of tissues. Although all isolates possessing the MrkD adhesin mediate the agglutination, in vitro, of erythrocytes treated with tannic acid, the
mrkD
gene is not conserved within species. The ability of a plasmid-borne
mrkD
gene product to mediate binding to type V collagen is associated frequently with strains of
K. oxytoca
and rarely with strains of
K. pneumoniae
. In
K. pneumoniae
, the MrkD adhesin is located within a chromosomally borne gene cluster and mediates binding to collagen types IV and V. The plasmid-borne determinant,
mrkD
1P
, and the chromosomally borne gene,
mrkD
1C
, are not genetically related. Some strains of enterobacteria possess a
mrkD
1C
allele that is associated with hemagglutinating activity but does not bind to either type IV or type V collagen.
Details
- Title: Subtitle
- Characterization of the Type 3 Fimbrial Adhesins of Klebsiella Strains
- Creators
- Tricia A. Schurtz Sebghati - Departments of MicrobiologyTimo K Korhonen - Departments of MicrobiologyDouglas B Hornick - Departments of MicrobiologySteven Clegg - Departments of Microbiology
- Resource Type
- Journal article
- Publication Details
- Infection and immunity, Vol.66(6), pp.2887-2894
- Publisher
- American Society for Microbiology
- DOI
- 10.1128/IAI.66.6.2887-2894.1998
- PMID
- 9596764
- PMCID
- PMC108286
- ISSN
- 0019-9567
- eISSN
- 1098-5522
- Language
- English
- Date published
- 06/1998
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984094491202771
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