Characterization of the human HOX 7 cDNA and identification of polymorphic markers

B. J PADANILAM; H. S STADLER; K. A MILLS; L. B MCLEOD; M SOLURSH; B LEE; F RAMIREZ; K. H BUETOW; J. C MURRAY

doi:10.1093/hmg/1.6.407

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Characterization of the human HOX 7 cDNA and identification of polymorphic markers

Journal article

Peer reviewed

Characterization of the human HOX 7 cDNA and identification of polymorphic markers

B. J PADANILAM, H. S STADLER, K. A MILLS, L. B MCLEOD, M SOLURSH, B LEE, F RAMIREZ, K. H BUETOW and J. C MURRAY

Human molecular genetics, Vol.1(6), pp.407-410

1992

DOI: 10.1093/hmg/1.6.407

PMID: 1284527

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Abstract

cDNA clones for a human HOX 7 gene obtained with homologous clones of Drosophila were used in human gene mapping studies. The human cDNA clone was isolated from a library constructed from human embryonic craniofacial material. The sequence of the cDNA demonstrates significant homology with mouse HOX 7. A search for RFLPs identified Mboll and BstEII variants. A CA dinucleotide repeat with 5 alleles was also identified and allowed placement of HOX 7 into a defined linkage map. Evidence for linkage disequilibrium was found with markers tested. These results place the human HOX 7 gene in a defined position on 4p.

Molecular Genetics

Fundamental and applied biological sciences. Psychology

Biological and medical sciences

Molecular and cellular biology

Genes. Genome

Details

Title: Subtitle: Characterization of the human HOX 7 cDNA and identification of polymorphic markers
Creators: B. J PADANILAM - Univ. Iowa, dep. biology, Iowa City IA 52242, United States
H. S STADLER - Univ. Iowa, dep. biology, Iowa City IA 52242, United States
K. A MILLS - Univ. Iowa, dep. biology, Iowa City IA 52242, United States
L. B MCLEOD - Univ. Iowa, dep. biology, Iowa City IA 52242, United States
M SOLURSH - Univ. Iowa, dep. biology, Iowa City IA 52242, United States
B LEE - Univ. Iowa, dep. biology, Iowa City IA 52242, United States
F RAMIREZ - Univ. Iowa, dep. biology, Iowa City IA 52242, United States
K. H BUETOW - Univ. Iowa, dep. biology, Iowa City IA 52242, United States
J. C MURRAY - Univ. Iowa, dep. biology, Iowa City IA 52242, United States
Resource Type: Journal article
Publication Details: Human molecular genetics, Vol.1(6), pp.407-410
DOI: 10.1093/hmg/1.6.407
PMID: 1284527
NLM abbreviation: Hum Mol Genet
ISSN: 0964-6906
eISSN: 1460-2083
Publisher: Oxford University Press; Oxford
Language: English
Date published: 1992
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
Record Identifier: 9984025434302771

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