Journal article
Characterizing academic performance in pediatric acute lymphoblastic leukemia with population-based achievement tests
Cancer reports, Vol.5(9), e1560
09/30/2021
DOI: 10.1002/cnr2.1560
PMCID: PMC9458490
PMID: 34596316
Abstract
Background Recent shifts from radiation to chemotherapy-based treatment for acute lymphoblastic leukemia (ALL) have contributed to reduced long-term morbidity. Despite this, ALL survivors remain at increased risk for long-term cognitive impairments. Aim To identify demographic and treatment factors associated with school performance in pediatric survivors of ALL. Methods We collected standardized test scores for reading, math, and science obtained in a school setting from grades 3-11 in 63 ALL survivors (46.0% boys). Most participants were assessed across multiple grades (median number of grades n = 5, range 1-7), and 269 observations were considered in the analyses. Treatment exposures were extracted from medical records. Socio-economic status was estimated using participation in free/reduced lunch programs at school. Mixed effects linear regression models were conducted to determine factors associated with school performance. Results ALL survivors' scores were comparable to state norms on reading, math, and science performances. On multivariable analysis, participation in free/reduced lunch programs was significantly associated with lower reading scores (beta = -12.52; 95% CI -22.26:-2.77, p = .01). Exposure to radiation during treatment was also associated with lower reading test scores (beta = -30.81, 95% CI -52.00:-9.62, p = .01). No significant associations between demographics and treatment parameters were observed for math and science test scores. Conclusions We utilized population-based achievement tests conducted from grades 3-11 to characterize school performance in ALL survivors. Our results imply that survivors with low socio-economic status and those exposed to radiation during treatment could benefit from early monitoring and intervention to maximize academic success.
Details
- Title: Subtitle
- Characterizing academic performance in pediatric acute lymphoblastic leukemia with population-based achievement tests
- Creators
- Hend M. Al-Kaylani - University of Iowa Hospitals and ClinicsErin E. Reasoner - University of IowaBradley T. Loeffler - University of IowaSarah L. Mott - University of IowaSusan Madasu - University of Iowa Hospitals and ClinicsAudrey Liu - University of Iowa Hospitals and ClinicsKathleen Langbehn - Department of Health Education and Behavior University of Florida Gainesville Florida USAAmy L. Conrad - University of Iowa Hospitals and ClinicsDavid Dickens - University of Iowa Hospitals and ClinicsAmanda Grafft - University of Iowa Hospitals and ClinicsLyndsay Harshman - University of Iowa Hospitals and ClinicsArunkumar J. Modi - University of Arkansas for Medical SciencesEllen van der Plas - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Cancer reports, Vol.5(9), e1560
- DOI
- 10.1002/cnr2.1560
- PMID
- 34596316
- PMCID
- PMC9458490
- NLM abbreviation
- Cancer Rep (Hoboken)
- ISSN
- 2573-8348
- eISSN
- 2573-8348
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- Monticello chapter of the Lion's Club University of Iowa Stead Family Children's Hospital Hematology/Oncology Division NIH P30 Cancer Center Support Grant; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 09/30/2021
- Academic Unit
- Psychiatry; Pediatric Psychology; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Hematology/Oncology; Radiation Oncology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984281751002771
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