Characterizing neurocognitive late effects in childhood leukemia survivors using a combination of neuropsychological and cognitive neuroscience measures

Ellen Van Der Plas; Lauren Erdman; Brian J Nieman; Rosanna Weksberg; Darci T Butcher; Deborah L O'connor; Susanne Aufreiter; Johann Hitzler; Sharon L Guger; Russell J Schachar; Shinya Ito; Brenda J Spiegler

doi:10.1080/09297049.2017.1386170

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Characterizing neurocognitive late effects in childhood leukemia survivors using a combination of neuropsychological and cognitive neuroscience measures

Journal article

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Characterizing neurocognitive late effects in childhood leukemia survivors using a combination of neuropsychological and cognitive neuroscience measures

Ellen Van Der Plas, Lauren Erdman, Brian J Nieman, Rosanna Weksberg, Darci T Butcher, Deborah L O'connor, Susanne Aufreiter, Johann Hitzler, Sharon L Guger, Russell J Schachar, …

Child neuropsychology, Vol.24(8), pp.999-1014

11/17/2018

DOI: 10.1080/09297049.2017.1386170

PMID: 29017430

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Abstract

Knowledge about cognitive late effects in survivors of childhood acute lymphoblastic leukemia (ALL) is largely based on standardized neuropsychological measures and parent reports. To examine whether cognitive neuroscience paradigms provided additional insights into neurocognitive and behavioral late effects in ALL survivors, we assessed cognition and behavior using a selection of cognitive neuroscience tasks and standardized measures probing domains previously demonstrated to be affected by chemotherapy. 130 ALL survivors and 158 control subjects, between 8 and 18 years old at time of testing, completed the n-back (working memory) and stop-signal (response inhibition) tasks. ALL survivors also completed standardized measures of intelligence (Wechsler Intelligence Scales [WISC-IV]), motor skills (Grooved Pegboard), math abilities (WIAT-III), and executive functions (Delis-Kaplan Executive Function System). Parents completed behavioral measures of executive functions (Behavior Rating Inventory of Executive Function [BRIEF]) and attention (Conners-3). ALL survivors exhibited deficiencies in working memory and response inhibition compared with controls. ALL survivors also exhibited deficits on WISC-IV working memory and processing speed, Grooved Pegboard, WIAT-III addition and subtraction fluency, and numerical operations, as well as DKEFS number-letter switching. Parent reports suggested more attention deficits (Conners-3) and behavioral difficulties (BRIEF) in ALL survivors compared with referenced norms. Low correspondence between standardized and experimental measures of working memory and response inhibition was noted. The use of cognitive neuroscience paradigms complements our understanding of the cognitive deficits evident after treatment of ALL. These measures could further delineate cognitive processes involved in neurocognitive late effects, providing opportunities to explore their underlying mechanisms.

neuropsychology

cognitive neuroscience

working memory

responseinhibition

Childhood cancer survivor

Details

Title: Subtitle: Characterizing neurocognitive late effects in childhood leukemia survivors using a combination of neuropsychological and cognitive neuroscience measures
Creators: Ellen Van Der Plas - Psychiatry Research, The Hospital for Sick Children
Lauren Erdman - Department of Computer Science, The University of Toronto
Brian J Nieman - Department of Medical Biophysics, The University of Toronto
Rosanna Weksberg - Institutes of Medical Science, The University of Toronto
Darci T Butcher - Genetics and Genome Biology, The Hospital for Sick Children Research Institute
Deborah L O'connor - Nutritional Sciences, The University of Toronto
Susanne Aufreiter - Translational Medicine, The Hospital for Sick Children Research Institute
Johann Hitzler - Department of Haematology/Oncology, The Hospital for Sick Children
Sharon L Guger - Department of Psychology, The Hospital for Sick Children
Russell J Schachar - Department of Psychiatry, Faculty of Medicine, The University of Toronto
Shinya Ito - Department of Pharmacology and Toxicology, Faculty of Medicine, The University of Toronto
Brenda J Spiegler - Department of Psychology, The Hospital for Sick Children
Resource Type: Journal article
Publication Details: Child neuropsychology, Vol.24(8), pp.999-1014
DOI: 10.1080/09297049.2017.1386170
PMID: 29017430
NLM abbreviation: Child Neuropsychol
ISSN: 0929-7049
eISSN: 1744-4136
Publisher: Routledge
Grant note: C17 - Children's Cancer and Blood Disorders 126586 / SickKids Garron Family Cancer Centre Ontario Institute for Cancer Research (10.13039/501100004203) Ontario Mental Health Foundation (10.13039/501100003248) Canadian Institutes of Health Research (10.13039/501100000024) Canadian Cancer Society Research Institute (10.13039/501100000015) Pediatric Oncology Group of Ontario (10.13039/501100000163)
Language: English
Date published: 11/17/2018
Academic Unit: Psychiatry
Record Identifier: 9984004182502771

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