Characterizing white matter health and organization in atherosclerotic vascular disease: A diffusion tensor imaging study

Kelly Rowe Bijanki; Stephan Arndt; Vincent A Magnotta; Peg Nopoulos; Sergio Paradiso; Joy T Matsui; Hans J Johnson; David J Moser

doi:10.1016/j.pscychresns.2013.07.011

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Characterizing white matter health and organization in atherosclerotic vascular disease: A diffusion tensor imaging study

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Characterizing white matter health and organization in atherosclerotic vascular disease: A diffusion tensor imaging study

Kelly Rowe Bijanki, Stephan Arndt, Vincent A Magnotta, Peg Nopoulos, Sergio Paradiso, Joy T Matsui, Hans J Johnson and David J Moser

Psychiatry research. Neuroimaging, Vol.214(3), pp.389-394

12/30/2013

DOI: 10.1016/j.pscychresns.2013.07.011

PMCID: PMC4175449

PMID: 24144509

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Abstract

Atherosclerotic vascular disease (AVD) is endemic to the developed world, with known negative outcomes for cognition and brain health. The effects of AVD on the white matter fibers of the brain have not yet been studied using diffusion tensor imaging (DTI). This study examined differences in fractional anisotropy (FA) between AVD and healthy comparison (HC) participants, and described the regional patterns of FA in each group. AVD participants were hypothesized to have lower FA than HC participants, indicating abnormalities in white matter health or organization. 1.5T diffusion tensor imaging was performed in 35 AVD and 22 HC participants. Mean FA measures were calculated for the white matter of the whole brain, as well for individual lobes. Globally and in every brain region measured except the temporal lobes, there were significant effects of group where AVD participants had lower FA values than their HC counterparts. Group differences in FA remained significant when controlled for white matter hyperintensity (WMH) volume, suggesting that FA detects white matter abnormality above and beyond what is measurable using the older WMH technique. These findings suggest a likely neural substrate underlying the changes in cognition and mood reported in atherosclerotic vascular disease patients.

Diffusion-weighted imaging

White matter disease

MRI

Leukoaraiosis

Atherosclerosis

Details

Title: Subtitle: Characterizing white matter health and organization in atherosclerotic vascular disease: A diffusion tensor imaging study
Creators: Kelly Rowe Bijanki - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, United States
Stephan Arndt - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, United States
Vincent A Magnotta - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, United States
Peg Nopoulos - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, United States
Sergio Paradiso - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, United States
Joy T Matsui - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, United States
Hans J Johnson - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, United States
David J Moser - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, United States
Resource Type: Journal article
Publication Details: Psychiatry research. Neuroimaging, Vol.214(3), pp.389-394
DOI: 10.1016/j.pscychresns.2013.07.011
PMID: 24144509
PMCID: PMC4175449
NLM abbreviation: Psychiatry Res Neuroimaging
ISSN: 0925-4927
eISSN: 1872-7506
Publisher: Elsevier Ireland Ltd
Language: English
Date published: 12/30/2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Electrical and Computer Engineering; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Biostatistics; Nursing; Injury Prevention Research Center; Medicine Administration
Record Identifier: 9984066134402771

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