Charcot-marie-tooth disease type 1X in women: Electrodiagnostic findings

Nivedita U Jerath; Laurie Gutmann; Chandan G Reddy; Michael E Shy

doi:10.1002/mus.25077

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Charcot-marie-tooth disease type 1X in women: Electrodiagnostic findings

Journal article

Peer reviewed

Charcot-marie-tooth disease type 1X in women: Electrodiagnostic findings

Nivedita U Jerath, Laurie Gutmann, Chandan G Reddy and Michael E Shy

Muscle & nerve, Vol.54(4), pp.728-732

10/2016

DOI: 10.1002/mus.25077

PMCID: PMC5588147

PMID: 26873881

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Abstract

Symptoms and signs in women with Charcot-Marie-Tooth disease type 1X (CMT1X) are often milder from those in men, but the available electrophysiologic evidence regarding CMT1X in women has been characterized in some patients as non-uniform or asymmetric. We retrospectively reviewed electrodiagnostic findings from 45 women and 31 men with CMT1X. Motor nerve conduction parameters in CMT1X women were less abnormal (P < 0.05), and a wider range of motor conduction velocities (CVs) were seen in women (P < 0.001) compared with men. In women, nerve conduction studies showed lack of conduction block without temporal dispersion. Motor CVs were more frequently in the normal range in women compared with men. There was no significant relationship to age of presentation and motor CV or compound muscle action potential in women. NCS parameters in CMT1X women did not demonstrate features suggestive of an acquired demyelinating neuropathy. Muscle Nerve, 2016 Muscle Nerve 54: -, 2016 Muscle Nerve 54: 728-732, 2016.

Humans

Middle Aged

Male

Neural Conduction - physiology

Electrodiagnosis - methods

Young Adult

Adolescent

Sex Factors

Aged, 80 and over

Adult

Female

Aged

Retrospective Studies

Charcot-Marie-Tooth Disease - physiopathology

Child

Charcot-Marie-Tooth Disease - diagnosis

Cohort Studies

Details

Title: Subtitle: Charcot-marie-tooth disease type 1X in women: Electrodiagnostic findings
Creators: Nivedita U Jerath - Department of Neurology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, Iowa, 52242, USA. nivedita-jerath@uiowa.edu
Laurie Gutmann - Department of Neurology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, Iowa, 52242, USA
Chandan G Reddy - Department of Neurosurgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Michael E Shy - Department of Neurology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, Iowa, 52242, USA
Resource Type: Journal article
Publication Details: Muscle & nerve, Vol.54(4), pp.728-732
DOI: 10.1002/mus.25077
PMID: 26873881
PMCID: PMC5588147
NLM abbreviation: Muscle Nerve
ISSN: 0148-639X
eISSN: 1097-4598
Publisher: United States
Grant note: U54 NS065712 / NINDS NIH HHS
Language: English
Date published: 10/2016
Academic Unit: Neurology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984013165902771

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