Charcot–Marie–Tooth Disease Type 1A: Influence of Body Mass Index on Nerve Conduction Studies and on the Charcot–Marie–Tooth Examination Score

Nivedita Jerath; Michael Shy

doi:10.1097/WNP.0000000000000415

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Charcot–Marie–Tooth Disease Type 1A: Influence of Body Mass Index on Nerve Conduction Studies and on the Charcot–Marie–Tooth Examination Score

Journal article

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Charcot–Marie–Tooth Disease Type 1A: Influence of Body Mass Index on Nerve Conduction Studies and on the Charcot–Marie–Tooth Examination Score

Nivedita Jerath and Michael Shy

Journal of clinical neurophysiology, Vol.34(6), pp.508-511

09/11/2017

DOI: 10.1097/WNP.0000000000000415

PMID: 28914656

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https://www.ncbi.nlm.nih.gov/pmc/articles/5679118View

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Abstract

PURPOSE:Charcot–Marie–Tooth Disease type 1A (CMT1A) is caused by a duplication of the peripheral myelin protein gene 22 at chromosome 17p11.2-12. There is limited data regarding whether body mass index (BMI) affects electrophysiological or clinical data in those with CMT1A.\nMETHODS:Electrophysiological data, the Charcot–Marie–Tooth examination score (CMTES) and BMI from 101 patients with known CMT1A were obtained and analyzed.\nRESULTS:When controlling for age, a higher BMI does not affect ulnar motor nerve conduction studies in those with CMT1A, but rather components of the CMTES (loss of pinprick and motor strength in the lower extremities).\nCONCLUSIONS:BMI and clinical components of the CMTES are correlated, but it is uncertain which came first—whether the loss of lower extremity pinprick sensation and motor strength results in a higher BMI or if higher BMI results in these signs.

Details

Title: Subtitle: Charcot–Marie–Tooth Disease Type 1A: Influence of Body Mass Index on Nerve Conduction Studies and on the Charcot–Marie–Tooth Examination Score
Creators: Nivedita Jerath - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa, U.S.A
Michael Shy
Resource Type: Journal article
Publication Details: Journal of clinical neurophysiology, Vol.34(6), pp.508-511
DOI: 10.1097/WNP.0000000000000415
PMID: 28914656
NLM abbreviation: J Clin Neurophysiol
ISSN: 0736-0258
eISSN: 1537-1603
Publisher: by the American Clinical Neurophysiology Society
Language: English
Date published: 09/11/2017
Academic Unit: Neurology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
Record Identifier: 9984070497102771

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