Journal article
Chart validation of inpatient International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) administrative diagnosis codes for venous thromboembolism (VTE) among intravenous immune globulin (IGIV) users in the Sentinel Distributed Database
Medicine (Baltimore), Vol.97(8), e9960
2018
DOI: 10.1097/MD.0000000000009960
PMCID: PMC5841980
PMID: 29465588
Abstract
Supplemental Digital Content is available in the text
The Sentinel Distributed Database (SDD) is a database of patient administrative healthcare records, derived from insurance claims and electronic health records, sponsored by the US Food and Drug Administration for evaluation of medical product outcomes. There is limited information on the validity of diagnosis codes for acute venous thromboembolism (VTE) in the SDD and administrative healthcare data more generally.
In this chart validation study, we report on the positive predictive value (PPV) of inpatient administrative diagnosis codes for acute VTE—pulmonary embolism (PE) or lower-extremity or site-unspecified deep vein thrombosis (DVT)—within the SDD. As part of an assessment of thromboembolic adverse event risk following treatment with intravenous immune globulin (IGIV), charts were obtained for 75 potential VTE cases, abstracted, and physician-adjudicated.
VTE status was determined for 62 potential cases. PPVs for lower-extremity DVT and/or PE were 90% (95% CI: 73–98%) for principal-position diagnoses, 80% (95% CI: 28–99%) for secondary diagnoses, and 26% (95% CI: 11–46%) for position-unspecified diagnoses (originating from physician claims associated with an inpatient stay). Average symptom onset was 1.5 days prior to hospital admission (range: 19 days prior to 4 days after admission).
PPVs for principal and secondary VTE discharge diagnoses were similar to prior study estimates. Position-unspecified diagnoses were less likely to represent true acute VTE cases.
Details
- Title: Subtitle
- Chart validation of inpatient International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) administrative diagnosis codes for venous thromboembolism (VTE) among intravenous immune globulin (IGIV) users in the Sentinel Distributed Database
- Creators
- Eric M Ammann - University of Iowa, College of Public HealthAdam Cuker - University of PennsylvaniaRyan M Carnahan - University of Iowa, College of Public HealthUsha S Perepu - University of Iowa, Carver College of MedicineScott K Winiecki - United States Food and Drug AdministrationMarin L Schweizer - University of Iowa, Carver College of MedicineCharles E Leonard - University of PennsylvaniaCandace C Fuller - Harvard Medical SchoolCrystal Garcia - Harvard Medical SchoolCole Haskins - University of IowaElizabeth A Chrischilles - University of Iowa, College of Public Health
- Resource Type
- Journal article
- Publication Details
- Medicine (Baltimore), Vol.97(8), e9960
- DOI
- 10.1097/MD.0000000000009960
- PMID
- 29465588
- PMCID
- PMC5841980
- NLM abbreviation
- Medicine (Baltimore)
- ISSN
- 0025-7974
- eISSN
- 1536-5964
- Publisher
- Wolters Kluwer Health
- Language
- English
- Date published
- 2018
- Academic Unit
- Pharmacy; Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9983995005102771
Metrics
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