Journal article
Chemical probes of a trisubstituted pyrrole to identify its protein target(s) in Plasmodium sporozoites
Bioorganic & medicinal chemistry letters, Vol.23(6), pp.1874-1877
03/15/2013
DOI: 10.1016/j.bmcl.2013.01.010
PMCID: PMC5509439
PMID: 23395653
Abstract
Trisubstituted pyrrole.
Malaria is a disease that has a major impact in many developing nations, especially on the African continent. There is a need to develop new therapeutics and prophylactic treatments against it. A trisubstituted pyrrole was recently found to inhibit infection of mammalian hepatocytes by Plasmodium sporozoites, but the target of this agent is not known. In this study trisubstituted pyrrole derivatives with different substituents on a piperidinyl nitrogen were prepared. We determined if modifications of the piperidinyl nitrogen would accommodate a drug–biotin linking strategy for affinity purification of the trisubstituted pyrrole’s target protein(s).
Details
- Title: Subtitle
- Chemical probes of a trisubstituted pyrrole to identify its protein target(s) in Plasmodium sporozoites
- Creators
- Tyrell Towle - Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, 115 S. Grand Ave., S311 PHAR, Iowa City, IA 52240, USAIsabel Chang - Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USARobert J Kerns - Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, 115 S. Grand Ave., S311 PHAR, Iowa City, IA 52240, USAPurnima Bhanot - Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
- Resource Type
- Journal article
- Publication Details
- Bioorganic & medicinal chemistry letters, Vol.23(6), pp.1874-1877
- DOI
- 10.1016/j.bmcl.2013.01.010
- PMID
- 23395653
- PMCID
- PMC5509439
- NLM abbreviation
- Bioorg Med Chem Lett
- ISSN
- 0960-894X
- eISSN
- 1464-3405
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 03/15/2013
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984065318502771
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