Journal article
Chemogenetic Tools for Causal Cellular and Neuronal Biology
Physiological reviews, Vol.98(1), pp.391-418
01/01/2018
DOI: 10.1152/physrev.00009.2017
PMCID: PMC5866359
PMID: 29351511
Abstract
Chemogenetic technologies enable selective pharmacological control of specific cell populations. An increasing number of approaches have been developed that modulate different signaling pathways. Selective pharmacological control over G protein-coupled receptor signaling, ion channel conductances, protein association, protein stability, and small molecule targeting allows modulation of cellular processes in distinct cell types. Here, we review these chemogenetic technologies and instances of their applications in complex tissues in vivo and ex vivo.
Details
- Title: Subtitle
- Chemogenetic Tools for Causal Cellular and Neuronal Biology
- Creators
- Deniz Atasoy - Department of Physiology, School of Medicine and Regenerative-Restorative Medicine Research Center (REMER), Istanbul Medipol University , Istanbul , Turkey ; and Janelia Research Campus, Howard Hughes Medical Institute , Ashburn, VirginiaScott M Sternson - Department of Physiology, School of Medicine and Regenerative-Restorative Medicine Research Center (REMER), Istanbul Medipol University , Istanbul , Turkey ; and Janelia Research Campus, Howard Hughes Medical Institute , Ashburn, Virginia
- Resource Type
- Journal article
- Publication Details
- Physiological reviews, Vol.98(1), pp.391-418
- Publisher
- United States
- DOI
- 10.1152/physrev.00009.2017
- PMID
- 29351511
- PMCID
- PMC5866359
- ISSN
- 0031-9333
- eISSN
- 1522-1210
- Grant note
- Howard Hughes Medical Institute
- Language
- English
- Date published
- 01/01/2018
- Academic Unit
- Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology
- Record Identifier
- 9984040231202771
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