Journal article
Chemokines and chemokine receptors in mucosal homeostasis at the intestinal epithelial barrier in inflammatory bowel disease
Inflammatory bowel diseases, Vol.14(7), pp.1000-1011
07/01/2008
DOI: 10.1002/ibd.20480
PMCID: PMC4114077
PMID: 18452220
Abstract
Chemokines, a large family of small chemoattractive cytokines, and their receptors play an integral role in the regulation of the immune response and homeostasis. The ability of chemokines to attract specific populations of immune cells sets them apart from other chemoattractants. Chemokines produced within the gastrointestinal mucosa are critical players in directing the balance between physiological and pathophysiological inflammation in health, inflammatory bowel disease (IBD), and the progression to colon cancer. In addition to the well-characterized role of chemokines in directed trafficking of immune cells to the gut mucosa, the expression of chemokine receptors on the cells of the epithelium makes them active participants in the chemokine signaling network. Recent findings demonstrate an important role for chemokines and chemokine receptors in epithelial barrier repair and maintenance as well as an intricate involvement in limiting metastasis of colonic carcinoma. Increased recognition of the association between barrier defects an inflammation and the subsequent progression to cancer in IBD thus implicates chemokines as key regulators of mucosal homeostasis and disease pathogenesis.
Details
- Title: Subtitle
- Chemokines and chemokine receptors in mucosal homeostasis at the intestinal epithelial barrier in inflammatory bowel disease
- Creators
- Noah P. Zimmerman - Medical College of WisconsinRebecca A. Vongsa - Medical College of WisconsinMichael K. Wendt - Medical College of WisconsinMichael B. Dwinell - Medical College of Wisconsin
- Resource Type
- Journal article
- Publication Details
- Inflammatory bowel diseases, Vol.14(7), pp.1000-1011
- DOI
- 10.1002/ibd.20480
- PMID
- 18452220
- PMCID
- PMC4114077
- NLM abbreviation
- Inflamm Bowel Dis
- ISSN
- 1078-0998
- eISSN
- 1536-4844
- Publisher
- Wiley
- Number of pages
- 12
- Grant note
- R01DK062066 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) DK 062022; R01 DK062066 / NIDDK NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 07/01/2008
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984460326102771
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