Chemoradiation in Advanced Head and Neck Cancers: A Comparison of two Radiosensitizers, Paclitaxel and Cisplatin

Sohit Paul Kanotra; Sonika Kanotra; Ashutosh Gupta; J Paul

doi:10.1007/s12070-011-0263-1

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Chemoradiation in Advanced Head and Neck Cancers: A Comparison of two Radiosensitizers, Paclitaxel and Cisplatin

Journal article

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Chemoradiation in Advanced Head and Neck Cancers: A Comparison of two Radiosensitizers, Paclitaxel and Cisplatin

Sohit Paul Kanotra, Sonika Kanotra, Ashutosh Gupta and J Paul

Indian journal of otolaryngology, and head, and neck surgery, Vol.63(3), pp.229-236

07/2011

DOI: 10.1007/s12070-011-0263-1

PMCID: PMC3138960

PMID: 22754800

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Abstract

To compare the locoregional control rates, survival outcome and toxicity profiles between two groups of patients of squamous cell carcinoma (SCC) of Head and Neck (Stage III & IV) receiving concomitant chemo-radiotherapy with Paclitaxel and Cisplatin. A prospective study was done on 94 previously untreated patients of histopathologically proved squamous cell carcinoma of head and neck region-AJCC stage III & IV (T3 & T4 with N0 -N3, M0) treated with concomitant chemoradiation. The patients were divided into two groups. Group A (44 patients) received concomitant chemotherapy (C.T.) with Paclitaxel 40 mgm/m2 while Group B (50 patients) received concomitant chemotherapy with Cisplatin 40 mgm/m2. All the patients in both the groups responded. In Group A (Paclitaxel + R.T.), complete response was seen in 72.7% and partial response in 27.3%. In Group B (Cisplatin +R.T.) complete response was seen in 52% and partial in 48%. At one year follow up, the locoregional control rate (LRC) in Group A was significantly higher as compared to that in Group B (65.9 vs. 46%,

Original

Chemoradiation

Cisplatin

Paclitaxel

Details

Title: Subtitle: Chemoradiation in Advanced Head and Neck Cancers: A Comparison of two Radiosensitizers, Paclitaxel and Cisplatin
Creators: Sohit Paul Kanotra - Department of ENT, St. Luke’s Roosevelt Hospital Centre, 515 W 59th St. Apt 16P, New York, NY 10019 USA
Sonika Kanotra - Government Medical College, Jammu, Jammu and Kashmir India
Ashutosh Gupta - Department of Radiation Oncology, Government Medical College, Jammu, Jammu and Kashmir India
J Paul - Department of E.N.T, ASCOMS, Jammu, Jammu and Kashmir India
Resource Type: Journal article
Publication Details: Indian journal of otolaryngology, and head, and neck surgery, Vol.63(3), pp.229-236
DOI: 10.1007/s12070-011-0263-1
PMID: 22754800
PMCID: PMC3138960
NLM abbreviation: Indian J Otolaryngol Head Neck Surg
ISSN: 2231-3796
eISSN: 0973-7707
Publisher: Springer-Verlag; India
Language: English
Date published: 07/2011
Academic Unit: Otolaryngology
Record Identifier: 9984006324802771

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