Journal article
Chemoreceptor stimulation interferes with regional hypoxic pulmonary vasoconstriction
Respiration physiology, Vol.71(2), pp.185-200
1988
DOI: 10.1016/0034-5687(88)90015-1
PMID: 3340818
Abstract
Hypoxemia interferes with the diversion of blood flow away from hypoxic regions of the lung, possibly through activation of the arterial chemoreceptor reflex. The purpose of this study was to determine if selective stimulation of carotid chemoreceptors reduces the diversion of flow (hypoxic vasoconstriction) when normal systemic oxygen levels are present. Chloralose anesthetized dogs were paralyzed and each lung was separately ventilated via a dual-lumen endobronchial tube. left pulmonary artery (Q̇L) and main pulmonary artery (Q̇T) blood flows were measured with electromagnetic flow probes. Chemoreceptors were stimulated by perfusion of the carotid sinuses with hypoxic, hypercapnic blood. Q̇L/Q̇T averaged 46±4, 29±2, and 36±4% during bilateral O
Details
- Title: Subtitle
- Chemoreceptor stimulation interferes with regional hypoxic pulmonary vasoconstriction
- Creators
- Mark W ChapleauL Britt WilsonTimothy J GregoryMichael G Levitzky
- Resource Type
- Journal article
- Publication Details
- Respiration physiology, Vol.71(2), pp.185-200
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0034-5687(88)90015-1
- PMID
- 3340818
- ISSN
- 0034-5687
- Language
- English
- Date published
- 1988
- Academic Unit
- Molecular Physiology and Biophysics; Internal Medicine
- Record Identifier
- 9984025426202771
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