Journal article
Chemosensitivity to triazene compounds and O6-alkylguanine-DNA alkyltransferase levels: Studies with blasts of leukaemic patients
Annals of oncology, Vol.6(4), pp.389-393
04/1995
DOI: 10.1093/oxfordjournals.annonc.a059189
PMID: 7619755
Abstract
Background clinical pilot study performed by our group showed that dacarbazine can induce a marked reduction of blast cells in patients with acute myelogenous leukaemia (AML). Leukaemic blasts (LB) from responsive patients showed low levels of O6-alkylguanine-DNA alkyltransferase(OGAT). Design An in vitro study was performed to evaluate OGAT levels and sensitivity to temozolomide (a triazene compound that spontaneously decomposes into the active metabolite of dacarbazine) in a relatively large number of LB samples. Results OGAT levels varied widely among the LB of different patients, with a mean value higher in acute lymphoblastic leukaemias than in AML. About 25% of LB obtained from patients with AML showed low OGAT activity, in the range corresponding to that observed in leukaemic patients responsive to dacarbazine in vivo. A reasonable inverse correlation was found between OGAT levels and LB sensitivity to temozolomide. Conclusions Triazenes could have a therapeutic potential in human leukaemias. Moreover, OGAT determination could provide rapid and reliable information about a patient's susceptibility to these antitumor agents.
Details
- Title: Subtitle
- Chemosensitivity to triazene compounds and O6-alkylguanine-DNA alkyltransferase levels: Studies with blasts of leukaemic patients
- Creators
- S. D'Atri - Istituto Dermopatico dell'ImmacolataD. Piccioni - University of Rome Tor VergataA. Castellano - University of Rome Tor VergataV. Tuorto - University of Rome Tor VergataA. Franchi - University of Rome Tor VergataK. Lu - Roswell Park Cancer InstituteN. Christiansen - Roswell Park Cancer InstituteS. Frankel - Roswell Park Cancer InstituteY. M. Rustum - Roswell Park Cancer InstituteG. Papa - University of Rome Tor VergataF. Mandelli - Sapienza University of RomeE. Bonmassar - Istituto Dermopatico dell'Immacolata
- Resource Type
- Journal article
- Publication Details
- Annals of oncology, Vol.6(4), pp.389-393
- Publisher
- Oxford University Press
- DOI
- 10.1093/oxfordjournals.annonc.a059189
- PMID
- 7619755
- ISSN
- 0923-7534
- eISSN
- 1569-8041
- Language
- English
- Date published
- 04/1995
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359869002771
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