Journal article
Chemotherapeutic Strategies for Treatment of Colorectal Cancer: Present and Future Developments
Clinical colorectal cancer, Vol.1(2), pp.121-127
2001
DOI: 10.3816/CCC.2001.n.013
PMID: 12445371
Abstract
Colorectal cancer is one of the most common malignancies in Western nations. Treatment with 5-fluorouracil and leucovorin resulting in inhibition of DNA synthesis after inhibition of thymidylate synthase is the most common strategy for adjuvant and systemic chemotherapy in this disease. However, the majority of patients still fail to respond to this combination; therefore, new chemotherapeutic strategies have been developed. This process has proceeded rapidly due to a more proper translation of preclinical results to the clinic. Knowledge of proximal parameters (drug activation, drug-target interaction) and distal parameters (cell growth inhibitory parameters and cell death parameters) in drug response should offer the opportunity to discriminate between sensitivity and resistance to chemotherapy and therapeutic selectivity. This clinical commentary presents a review of a symposium held at the Vrije Universiteit Medical Center, Amsterdam, The Netherlands, which focused on both the preclinical and clinical aspects relating to the treatment of colorectal cancer.
Details
- Title: Subtitle
- Chemotherapeutic Strategies for Treatment of Colorectal Cancer: Present and Future Developments
- Creators
- Harold H.J. Backus - Vrije Universiteit AmsterdamYoucef M. Rustum - Roswell Park Cancer InstituteCornelius J. van Groeningen - Vrije Universiteit AmsterdamGodefridus J. Peters - Vrije Universiteit Amsterdam
- Resource Type
- Journal article
- Publication Details
- Clinical colorectal cancer, Vol.1(2), pp.121-127
- Publisher
- Elsevier Inc
- DOI
- 10.3816/CCC.2001.n.013
- PMID
- 12445371
- ISSN
- 1533-0028
- eISSN
- 1938-0674
- Language
- English
- Date published
- 2001
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359668702771
Metrics
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