Journal article
Chemotherapy and targeted treatments of breast sarcoma by histologic subtype
Expert review of anticancer therapy, Vol.21(6), pp.591-604
06/03/2021
DOI: 10.1080/14737140.2021.1880327
PMID: 33554686
Abstract
Introduction: Breast sarcomas (BS) are uncommon and often present both diagnostic and therapeutic challenges. Historically, radical surgery has been the mainstay of treatment for localized breast sarcomas. On the other hand, in advanced disease, since they are a heterogeneous group of neoplasms consisting of several different subtypes including angiosarcoma, phyllodes tumor, and pleomorphic undifferentiated sarcoma, there is a lack of proven specific therapy. As a result, their treatment is based on the soft tissue sarcoma (STS) paradigm, whereas histotype-tailored approaches apply to specific subtypes like dermatofibrosarcoma protuberans. To date, advanced stages constitute an incurable form of disease and chemotherapy remains the cornerstone of treatment with the aim of palliation of symptoms and increase in survival.
Areas covered: In this manuscript, we review the clinicopathologic characteristics of the most common subtypes of BS, as well as the current treatment landscape of BS, with a particular focus on opportunities and challenges provided by new targeted molecules and immunotherapy.
Expert opinion: The treatment approach of advanced BS is based on the pathologic subtype. A true breakthrough has still to be obtained, as the development of new agents in BS suffers from the same weaknesses as in other STS.
Details
- Title: Subtitle
- Chemotherapy and targeted treatments of breast sarcoma by histologic subtype
- Creators
- Stefania Kokkali - St Savvas Anticanc Hosp, Med Oncol Clin 1, Athens, GreeceAthina Stravodimou - Lausanne Univ Hosp, Dept Oncol, Lausanne, SwitzerlandJose Duran-Moreno - National and Kapodistrian University of AthensNektarios Koufopoulos - National and Kapodistrian University of AthensIoannis A. Voutsadakis - Essar Steel AlgomaAntonia Digklia - Lausanne Univ Hosp, Dept Oncol, Lausanne, Switzerland
- Resource Type
- Journal article
- Publication Details
- Expert review of anticancer therapy, Vol.21(6), pp.591-604
- Publisher
- Taylor & Francis
- DOI
- 10.1080/14737140.2021.1880327
- PMID
- 33554686
- ISSN
- 1473-7140
- eISSN
- 1744-8328
- Number of pages
- 14
- Language
- English
- Date published
- 06/03/2021
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806603802771
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