Child Maltreatment Moderates the Association of MAOA with Symptoms of Depression and Antisocial Personality Disorder

Steven R. H Beach; Gene H Brody; Tracy D Gunter; Hans Packer; Pamela Wernett; Robert A Philibert

doi:10.1037/a0018074

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Child Maltreatment Moderates the Association of MAOA with Symptoms of Depression and Antisocial Personality Disorder

Journal article

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Child Maltreatment Moderates the Association of MAOA with Symptoms of Depression and Antisocial Personality Disorder

Steven R. H Beach, Gene H Brody, Tracy D Gunter, Hans Packer, Pamela Wernett and Robert A Philibert

Journal of family psychology, Vol.24(1), pp.12-20

02/2010

DOI: 10.1037/a0018074

PMCID: PMC2839928

PMID: 20175604

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https://www.ncbi.nlm.nih.gov/pmc/articles/2839928View

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Abstract

There is a growing body of data indicating that gene X child maltreatment interactions at Monoamine Oxidase A (MAOA ) play a role in vulnerability to symptoms of Antisocial Personality Disorder (ASPD) but not Major Depression (MD). Using a sample of 538 participants from the Iowa Adoption Studies, we introduce a conceptual model that highlights two distinct pathways from child maltreatment to symptoms of MD, suggesting that maltreatment has different effects depending on genotype and highlighting the importance of including the indirect pathway through ASPD. As predicted by the model, high activity alleles predispose to symptoms of MD in the context of child maltreatment whereas low activity alleles predispose to symptoms of ASPD. We conclude that the GxE interplay at this locus ( MAOA ) contributes to both symptoms of ASPD and MD and that careful specification of child maltreatment may be essential if genetic association research is to produce replicable results.

Child Maltreatment

ASPD

Depression

Family

Gene X Environment

MAOA

Details

Title: Subtitle: Child Maltreatment Moderates the Association of MAOA with Symptoms of Depression and Antisocial Personality Disorder
Creators: Steven R. H Beach - Department of Psychology, University of Georgia, Athens, GA
Gene H Brody - Center for Family Research, University of Georgia, Athens, GA
Tracy D Gunter - Department of Neurology and Psychiatry, St Louis University School of Medicine, St Louis, MO
Hans Packer - Department of Psychiatry, The University of Iowa, Iowa City, IA
Pamela Wernett - Department of Psychiatry, The University of Iowa, Iowa City, IA
Robert A Philibert - Neuroscience Program and Department of Psychiatry, The University of Iowa, Iowa City, IA
Resource Type: Journal article
Publication Details: Journal of family psychology, Vol.24(1), pp.12-20
DOI: 10.1037/a0018074
PMID: 20175604
PMCID: PMC2839928
NLM abbreviation: J Fam Psychol
ISSN: 0893-3200
eISSN: 1939-1293
Grant note: name: Sponsor name not included, award: DA015789, DA010923; DA02173603, 1P30DA027827
Language: English
Date published: 02/2010
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003930102771

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