Journal article
Childhood Academic Performance: A Potential Marker of Genetic Liability to Autism
Journal of autism and developmental disorders, Vol.53(5), pp.1989-2005
05/2023
DOI: 10.1007/s10803-022-05459-5
PMCID: PMC9932999
PMID: 35194728
Abstract
Autism spectrum disorder (ASD), a heritable neurodevelopmental disorder, confers genetic liability that is often expressed among relatives through subclinical, genetically-meaningful traits, or endophenotypes. For instance, relative to controls, parents of individuals with ASD differ in language-related skills, with differences emerging in childhood. To examine ASD-related endophenotypes, this study investigated developmental academic profiles among clinically unaffected siblings of individuals with ASD (n = 29). Lower performance in language-related skills among siblings mirrored previously-reported patterns among parents, which were also associated with greater subclinical ASD-related traits in themselves and their parents, and with greater symptom severity in their sibling with ASD. Findings demonstrated specific phenotypes, derived from standardized academic testing, that may represent childhood indicators of genetic liability to ASD in first-degree relatives.
Details
- Title: Subtitle
- Childhood Academic Performance: A Potential Marker of Genetic Liability to Autism
- Creators
- Janna Guilfoyle - Roxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, 2240 N Campus Dr., Evanston, IL, 60208, USA.Molly Winston - Roxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, 2240 N Campus Dr., Evanston, IL, 60208, USA.John Sideris - University of Southern CaliforniaGary E. Martin - St. John's UniversityKritika Nayar - Roxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, 2240 N Campus Dr., Evanston, IL, 60208, USA.Lauren Bush - Roxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, 2240 N Campus Dr., Evanston, IL, 60208, USA.Tom Wassink - University of IowaMolly Losh - Roxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, 2240 N Campus Dr., Evanston, IL, 60208, USA. m-losh@northwestern.edu.
- Resource Type
- Journal article
- Publication Details
- Journal of autism and developmental disorders, Vol.53(5), pp.1989-2005
- Publisher
- Springer Nature
- DOI
- 10.1007/s10803-022-05459-5
- PMID
- 35194728
- PMCID
- PMC9932999
- ISSN
- 0162-3257
- eISSN
- 1573-3432
- Number of pages
- 17
- Grant note
- R01DC010191; R03MH107834; P30DC012035 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA BCS-0820394 / National Science Foundation; National Science Foundation (NSF) 1337 / Autism Speaks
- Language
- English
- Electronic publication date
- 02/23/2022
- Date published
- 05/2023
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984281752602771
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