Journal article
Childhood Age and Associations Between Childhood Metabolic Syndrome and Adult Risk for Metabolic Syndrome, Type 2 Diabetes Mellitus and Carotid Intima Media Thickness: The International Childhood Cardiovascular Cohort Consortium
Journal of the American Heart Association, Vol.6(8), e005632
08/01/2017
DOI: 10.1161/JAHA.117.005632
PMCID: PMC5586423
PMID: 28862940
Abstract
Background-There is paucity of knowledge concerning the specific age in youth when the associations of metabolic syndrome (MetS) begin to be operative. Thus, we investigated the relation of age to the associations of childhood MetS with adult MetS, type 2 diabetes mellitus and high carotid intima-media thickness.
Methods and Results-Five thousand eight-hundred three participants were analyzed in 4 cohort studies (Cardiovascular Risk in Young Finns, Bogalusa Heart Study, Princeton Lipid Research Study, Insulin Study). International cutoffs and previously used 75th percentile cutoffs were used for children to define MetS and its components. Mean follow-up period was 22.3 years. Logistic regression was used to calculate risk ratios and 95% confidence intervals. Childhood MetS and overweight were associated with over 2.4-fold risk for adult MetS from the age of 5 years onward. Risk for type 2 diabetes mellitus was increased from the age of 8 (risk ratio, 2.6-4.1; 95% confidence interval, 1.35-6.76 and 1.12-7.24, respectively) onward for the 2 childhood MetS criteria based on international cut-off values and for childhood overweight. Risk for high carotid intima-media thickness was significant at ages 11 to 18 years in relation to childhood MetS or overweight (risk ratio, 2.44-4.22; 95% confidence interval, 1.55-3.55 and 2.55-5.66, respectively). Continuous childhood MetS score was associated with adult MetS from the age of 5, with type 2 diabetes mellitus from the age of 14 and with high carotid intima-media thickness from the age of 11 years onward.
Conclusions-Adult MetS was predicted by MetS in childhood beginning at age 5. However, adult type 2 diabetes mellitus and subclinical atherosclerosis were not predicted by childhood data until after age 8. Body mass index measurement alone at the same age points provided similar findings.
Details
- Title: Subtitle
- Childhood Age and Associations Between Childhood Metabolic Syndrome and Adult Risk for Metabolic Syndrome, Type 2 Diabetes Mellitus and Carotid Intima Media Thickness: The International Childhood Cardiovascular Cohort Consortium
- Creators
- Juha Koskinen - University of TurkuCostan G. Magnussen - University of TasmaniaAlan Sinaiko - University of MinnesotaJessica Woo - Cincinnati Children's Hospital Medical CenterElaine Urbina - Cincinnati Children's Hospital Medical CenterDavid R. Jacobs - University of MinnesotaJulia Steinberger - University of MinnesotaRonald Prineas - Wake Forest UniversityMatthew A. Sabin - Royal Children's HospitalTrudy Burns - University of IowaGerald Berenson - Tulane UniversityLydia Bazzano - Tulane UniversityAlison Venn - University of TasmaniaJorma S. A. Viikari - University of TurkuNina Hutri-Kahonen - University of TampereOlli Raitakari - Turku University HospitalTerence Dwyer - Royal Children's HospitalMarkus Juonala - Turku University Hospital
- Resource Type
- Journal article
- Publication Details
- Journal of the American Heart Association, Vol.6(8), e005632
- Publisher
- Wiley
- DOI
- 10.1161/JAHA.117.005632
- PMID
- 28862940
- PMCID
- PMC5586423
- ISSN
- 2047-9980
- eISSN
- 2047-9980
- Number of pages
- 16
- Grant note
- 126925; 121584; 124282; 129378; 117787; 41071 / Academy of Finland Kuopio Turku University Hospital Medical Fund Finnish Foundation of Cardiovascular Research R01HL121230 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) UL1TR001425 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) Turku University Hospital Medical Fund Paavo Nurmi Foundation Yrjo Jahnsson Foundation Finnish Cultural Foundation; Finnish IT center for science Social Insurance Institution of Finland R01 HL121230 / National Institutes of Health (NIH/NICHD); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) APP1098369 / National Health and Medical Research Council Project Grant; National Health and Medical Research Council of Australia Juho Vainio Foundation R01AG041200 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Sigrid Juselius Foundation 100849 / National Heart Foundation of Australia Future Leader Fellowship; National Heart Foundation of Australia Tampere Turku University Hospital Medical Fund
- Language
- English
- Date published
- 08/01/2017
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984363594002771
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