Journal article
Childhood BMI and Fasting Glucose and Insulin Predict Adult Type 2 Diabetes: The International Childhood Cardiovascular Cohort (i3C) Consortium
Diabetes care, Vol.43(11), pp.2821-2829
11/01/2020
DOI: 10.2337/dc20-0822
PMCID: PMC7576414
PMID: 32873588
Abstract
OBJECTIVE To examine childhood BMI, fasting glucose, and insulin in relation to incident adult type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS We used data from the International Childhood Cardiovascular Cohort (i3C) Consortium. Data included childhood (age 3-19 years) measurements obtained during the 1970s-1990s; a health questionnaire, including self-report of adult T2DM (occurrence age, medication use) obtained at mean age 40 years; and a medical diagnosis registry (Finland). RESULTS The sample included 6,738 participants. Of these, 436 (6.5%) reported onset of T2DM between ages 20 and 59 (mean 40.8) years, and 86% of them reported use of a confirmed antidiabetic medication. BMI and glucose (age and sex standardized) were associated with incident T2DM after adjustment for cohort, country, sex, race, age, and calendar year of measurement. Increasing levels of childhood BMI and glucose were related to an incrementally increased risk of T2DM beginning at age 30 years, beginning at cut points CONCLUSIONS Childhood BMI and glucose are predictors of adult T2DM at levels previously considered to be within the normal range. These easy-to-apply measurements are appealing from a clinical perspective. Fasting insulin has the potential to be an additional predictor.
Details
- Title: Subtitle
- Childhood BMI and Fasting Glucose and Insulin Predict Adult Type 2 Diabetes: The International Childhood Cardiovascular Cohort (i3C) Consortium
- Creators
- Tian Hu - University of MinnesotaDavid R. Jacobs - University of MinnesotaAlan R. Sinaiko - University of MinnesotaLydia A. Bazzano - Tulane UniversityTrudy L. Burns - University of IowaStephen R. Daniels - University of Colorado DenverTerry Dwyer - University of OxfordNina Hutri-Kahonen - Tampere University HospitalMarkus Juonala - Turku University HospitalKari A. Murdy - University of MinnesotaRonald J. Prineas - Wake Forest UniversityOlli T. Raitakari - University of TurkuElaine M. Urbina - Cincinnati Children's Hospital Medical CenterAlison Venn - University of TasmaniaJessica G. Woo - Cincinnati Children's Hospital Medical CenterJulia Steinberger - University of Minnesota
- Resource Type
- Journal article
- Publication Details
- Diabetes care, Vol.43(11), pp.2821-2829
- DOI
- 10.2337/dc20-0822
- PMID
- 32873588
- PMCID
- PMC7576414
- NLM abbreviation
- Diabetes Care
- ISSN
- 0149-5992
- eISSN
- 1935-5548
- Publisher
- Amer Diabetes Assoc
- Number of pages
- 9
- Grant note
- Kuopio University Hospital Medical Fund 126925; 121584; 124282; 129378; 117787; 41071 / Academy of Finland Finnish Foundation of Cardiovascular Research Paavo Nurmi Foundation Yrjo Jahnsson Foundation Turku University Hospital Medical Fund Finnish Cultural Foundation; Finnish IT center for science Social Insurance Institution of Finland R01-HL-121230 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Juho Vainio Foundation Tampere University Hospital Medical Fund APP1098369; APP211316 / Australian National Health and Medical Research Council Project; National Health and Medical Research Council of Australia Sigrid Juselius Foundation
- Language
- English
- Date published
- 11/01/2020
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984363572902771
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