Childhood Predictors of the Metabolic Syndrome in Middle-Aged Adults: The Muscatine Study

Trudy L. Burns; Elena M. Letuchy; Richard Paulos; John Witt

doi:10.1016/j.jpeds.2009.04.044

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Childhood Predictors of the Metabolic Syndrome in Middle-Aged Adults: The Muscatine Study

Journal article

Open access

Peer reviewed

Childhood Predictors of the Metabolic Syndrome in Middle-Aged Adults: The Muscatine Study

Trudy L. Burns, Elena M. Letuchy, Richard Paulos and John Witt

The Journal of pediatrics, Vol.155(3), pp.S5.e17-S5.e26

2009

DOI: 10.1016/j.jpeds.2009.04.044

PMCID: PMC2739835

PMID: 19732563

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Abstract

To investigate the association between components of the metabolic syndrome (MetS) measured during childhood/adolescence, and adult MetS. This investigation focused on members of the Muscatine Study Longitudinal Adult Cohort. Predictor variables were risk factor measurements obtained between 1970 and 1981 when cohort members participated in school survey examinations. Risk factor measurements obtained between 1982 and 2008 when cohort members participated in follow-up examinations as young and middle-aged adults were used for MetS classification. 33.0% (29.7% of 474 women; 37.0% of 384 men) of cohort members were classified as having the MetS. The initial MetS classification occurred at ages ranging from 23 to 52 years, with a mean age of 37.2 years (SD = 7.4). Cohort members with the MetS had significantly higher body mass index, systolic blood pressure, and triglycerides at the time they participated in the school survey examinations ( P < .0001). Estimated probabilities of remaining MetS free at age 35 for those whose school survey body mass index and triglyceride measurements were both <50th vs ≥75th percentiles were strikingly different (0.94 vs 0.42). BMI is the strongest childhood predictor of adult MetS. Early identification of at-risk children may reduce the burden of atherosclerotic cardiovascular disease.

MetS

NCEP

ROC

NHANES

TRIG

CHOL

PMSWG

BMI

YAF

Details

Title: Subtitle: Childhood Predictors of the Metabolic Syndrome in Middle-Aged Adults: The Muscatine Study
Creators: Trudy L. Burns - University of Iowa
Elena M. Letuchy - University of Iowa
Richard Paulos - University of Iowa
John Witt - University of Iowa
Resource Type: Journal article
Publication Details: The Journal of pediatrics, Vol.155(3), pp.S5.e17-S5.e26
Publisher: Mosby, Inc
DOI: 10.1016/j.jpeds.2009.04.044
PMID: 19732563
PMCID: PMC2739835
ISSN: 0022-3476
eISSN: 1097-6833
Language: English
Date published: 2009
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984363641002771

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