Childhood adiposity, adult adiposity, and the ACE gene insertion/deletion polymorphism: evidence of gene-environment interaction effects on adult blood pressure and hypertension status in adulthood

Cong Sun; Anne-Louise Ponsonby; John B Carlin; Minh Bui; Costan G Magnussen; Trudy L Burns; Terho Lehtimaki; Nicole H Wardrop; Markus Juonala; Jorma S A Viikari; Alison J Venn; Olli T Raitakari; Terence Dwyer

doi:10.1097/HJH.0000000000001816

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Childhood adiposity, adult adiposity, and the ACE gene insertion/deletion polymorphism: evidence of gene-environment interaction effects on adult blood pressure and hypertension status in adulthood

Journal article

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Childhood adiposity, adult adiposity, and the ACE gene insertion/deletion polymorphism: evidence of gene-environment interaction effects on adult blood pressure and hypertension status in adulthood

Cong Sun, Anne-Louise Ponsonby, John B Carlin, Minh Bui, Costan G Magnussen, Trudy L Burns, Terho Lehtimaki, Nicole H Wardrop, Markus Juonala, Jorma S A Viikari, …

Journal of hypertension, Vol.36(11), pp.2168-2176

11/2018

DOI: 10.1097/HJH.0000000000001816

PMCID: PMC6452450

PMID: 29939946

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https://www.ncbi.nlm.nih.gov/pmc/articles/6452450View

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Abstract

Genetic variants may modify the associations of adiposity measures with blood pressure (BP) and hypertension. The insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene is an attractive candidate. To examine interaction effects between I/D polymorphism and adiposity measures (BMI, waist circumference, waist-to-hip ratio, and skinfold thickness) during childhood and adulthood in relation to adult BP and hypertension. Data were available for 4835 participants from three prospective cohort studies. Multivariable linear regression models for adult SBP and DBP, and multivariable logistic regression models for hypertension were fit that included interaction effects between child or adult adiposity and I/D polymorphism. Evidence for interaction effects on BP/hypertension were found across the three studies. Compared with childhood measures, the effect modification appeared to be more consistent when using adult adiposity. In particular, the adverse effects of greater adult waist circumference on increasing adult SBP and DBP appeared to be larger among carriers of ACE DD (or GG) [adjusted linear regression coefficients 0.26, 95% CI (0.21-0.31) and 0.28 (0.24-0.32) for SBP and DBP, respectively] and ID (or AG) genotypes [0.25 (0.21-0.29) and 0.25 (0.21-0.28), respectively], whereas those with II (or AA) genotypes had smaller effects [0.15 (0.09-0.21) and 0.19 (0.13-0.23)]. ACE genetic variation may modify the effect of adult adiposity on increasing BP and risk of hypertension in adulthood. Individuals with ACE DD (or GG) and/or ID (or AG) genotypes, compared with those with II (or AA) genotype, appear more vulnerable to the impact of excess adiposity.

Adiposity

Adult

Blood Pressure - genetics

Body Mass Index

Child

Gene-Environment Interaction

Genotype

Humans

Hypertension - etiology

INDEL Mutation

Pediatric Obesity - complications

Peptidyl-Dipeptidase A - genetics

Polymorphism, Genetic

Prospective Studies

Skinfold Thickness

Waist Circumference

Waist-Hip Ratio

Details

Title: Subtitle: Childhood adiposity, adult adiposity, and the ACE gene insertion/deletion polymorphism: evidence of gene-environment interaction effects on adult blood pressure and hypertension status in adulthood
Creators: Cong Sun - Royal Children's Hospital
Anne-Louise Ponsonby - Royal Children's Hospital
John B Carlin - Royal Children's Hospital
Minh Bui - The University of Melbourne
Costan G Magnussen - Turku University Hospital
Trudy L Burns - University of Iowa
Terho Lehtimaki - University of Tampere
Nicole H Wardrop - Royal Children's Hospital
Markus Juonala - University of Turku
Jorma S A Viikari - Turku University Hospital
Alison J Venn - University of Tasmania
Olli T Raitakari - Turku University Hospital
Terence Dwyer - Royal Children's Hospital
Resource Type: Journal article
Publication Details: Journal of hypertension, Vol.36(11), pp.2168-2176
DOI: 10.1097/HJH.0000000000001816
PMID: 29939946
PMCID: PMC6452450
NLM abbreviation: J Hypertens
ISSN: 0263-6352
eISSN: 1473-5598
Grant note: R01 HL048050 / NHLBI NIH HHS P30 ES005605 / NIEHS NIH HHS R01 HL061857 / NHLBI NIH HHS R01 HL054730 / NHLBI NIH HHS M01 RR000059 / NCRR NIH HHS
Language: English
Date published: 11/2018
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984363624302771

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