Childhood-onset chronic inflammatory demyelinating polyradiculoneuropathy with cranial nerve involvement

Fiona Costello; Andrew G Lee; Adel K Afifi; Praful Kelkar; Randy H Kardon; Matthew White

doi:10.1177/08830738020170111201

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Childhood-onset chronic inflammatory demyelinating polyradiculoneuropathy with cranial nerve involvement

Journal article

Peer reviewed

Childhood-onset chronic inflammatory demyelinating polyradiculoneuropathy with cranial nerve involvement

Fiona Costello, Andrew G Lee, Adel K Afifi, Praful Kelkar, Randy H Kardon and Matthew White

Journal of child neurology, Vol.17(11), pp.819-823

11/2002

DOI: 10.1177/08830738020170111201

PMID: 12585721

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Abstract

A 17-year-old male presented with chronic diplopia and generalized motor weakness. He was previously diagnosed with chronic inflammatory demyelinating polyradiculoneuropathy and acute disseminated encephalomyelitis in childhood. Cranial magnetic resonance imaging (MRI) revealed a rarely reported finding of thickening and enhancement of multiple cranial nerves. Nerve conduction studies and electromyography showed peripheral nerve demyelination with axonal involvement. There was improvement in the clinical examination, MRI, and electrophysiologic studies after combined corticosteroid and plasma exchange therapy. We review the clinical presentation, course, and response to therapy among children with chronic inflammatory demyelinating polyradiculoneuropathy, with specific emphasis on the frequency and pattern of cranial nerve involvement.

Electromyography

Magnetic Resonance Imaging

Muscle Weakness - etiology

Humans

Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - complications

Male

Treatment Outcome

Combined Modality Therapy

Diabetes Mellitus, Type 1 - complications

Plasma Exchange

Adrenal Cortex Hormones - therapeutic use

Cranial Nerve Diseases - complications

Encephalomyelitis, Acute Disseminated - complications

Adolescent

Cranial Nerve Diseases - therapy

Diplopia - etiology

Details

Title: Subtitle: Childhood-onset chronic inflammatory demyelinating polyradiculoneuropathy with cranial nerve involvement
Creators: Fiona Costello - University of Iowa
Andrew G Lee - University of Iowa, Ophthalmology and Visual Sciences
Adel K Afifi - University of Iowa, Neurology
Praful Kelkar - University of Iowa
Randy H Kardon - University of Iowa, Ophthalmology and Visual Sciences
Matthew White - University of Iowa
Resource Type: Journal article
Publication Details: Journal of child neurology, Vol.17(11), pp.819-823
DOI: 10.1177/08830738020170111201
PMID: 12585721
NLM abbreviation: J Child Neurol
ISSN: 0883-0738
eISSN: 1708-8283
Publisher: United States
Language: English
Date published: 11/2002
Academic Unit: Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983980018802771

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