Journal article
Childhood psychosocial stress is linked with impaired vascular endothelial function, lower SIRT1, and oxidative stress in young adulthood
American journal of physiology. Heart and circulatory physiology, Vol.321(3), pp.H532-H541
09/01/2021
DOI: 10.1152/ajpheart.00123.2021
PMCID: PMC8461842
PMID: 34328346
Abstract
Adverse childhood experiences (ACEs) are psychosocial stressors that occur during sensitive developmental windows and are associated with increased lifetime cardiovascular disease (CVD) risk in a dose-dependent manner. Vascular endothelial dysfunction is a pathophysiological mechanism that promotes hypertension and CVD and may be a mechanism by which ACEs contribute to lifetime CVD risk. We examined whether exposure to ACEs is associated with reduced vascular endothelial function (VEF) in otherwise healthy, young adult women (20.7 +/- 3 yr) with (ACE(+)) versus without (ACE(-)) ACEs, explored whether differences in circulating sirtuin 1 (SIRT1) or systemic oxidative stress could explain ACEs-related differences in VEF, and examined the ability of a pilot, 8-wk exercise intervention to augment VEF and SIRT1 or reduce oxidized LDL cholesterol (oxLDL) in ACE(+) young adult women. Forty-two otherwise healthy young adults completed this study. Prior to the intervention, VEF (P = 0.002) and SIRT1 (P = 0.004) were lower in the ACE(+) than ACE(-) group, but oxLDL concentrations were not different (P = 0.77). There were also significant relationships (P <= 0.04) among flow-mediated dilation (FMD), SIRT1, and oxLDL in the ACE(+), but not ACE(-) group. Adjusting for circulating SIRT1 and oxLDL reduced the differences in FMD observed between groups (P = 0.10), but only SIRT1 was a significant adjuster of the means (P < 0.05). Finally, the exercise intervention employed was unable to enhance VEF or SIRT1 in the ACE(+) exercise group. Our data suggest that ACEs likely increase susceptibility to hypertension and CVD by causing endothelial dysfunction, perhaps through a SIRT1 pathway-related mechanism.
NEW & NOTEWORTHY Our study provides novel evidence that young adult women with moderate-to-severe adverse childhood experience (ACE) exposure present impaired endothelial function and lower circulating sirtuin 1 (SIRT1) concentrations than agematched controls. However, an 8-wk exercise intervention was unable to augment endothelial function or SIRT1 concentrations in a subset of those with ACEs. Our data suggest that ACEs-related impairments in endothelial function may be secondary to decreased NO bioavailability via SIRT1 and/or oxidative stress-related mechanisms.
Details
- Title: Subtitle
- Childhood psychosocial stress is linked with impaired vascular endothelial function, lower SIRT1, and oxidative stress in young adulthood
- Creators
- Nathaniel D. M. Jenkins - University of IowaEmily M. Rogers - University of IowaNile F. Banks - University of IowaPatrick M. Tomko - RMIT UniversityChristina M. Sciarrillo - Oklahoma State UniversitySam R. Emerson - Oklahoma State UniversityAshlee Taylor - University of OklahomaT. Kent Teague - University of Oklahoma
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Heart and circulatory physiology, Vol.321(3), pp.H532-H541
- DOI
- 10.1152/ajpheart.00123.2021
- PMID
- 34328346
- PMCID
- PMC8461842
- NLM abbreviation
- Am J Physiol Heart Circ Physiol
- ISSN
- 0363-6135
- eISSN
- 1522-1539
- Publisher
- Amer Physiological Soc
- Number of pages
- 10
- Grant note
- P20GM109097 / Center for Integrative Research on Childhood Adversity Grant through National Institute of General Medical Sciences
- Language
- English
- Date published
- 09/01/2021
- Academic Unit
- Center for Social Science Innovation; Injury Prevention Research Center; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984259400402771
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