Journal article
Childhood trauma is associated with developmental trajectories of EEG coherence, alcohol-related outcomes, and PTSD symptoms
Psychological Medicine, Vol.54(15), pp.4302-4315
11/01/2024
DOI: 10.1017/S0033291724002599
PMCID: PMC11650155
PMID: 39620481
Abstract
BackgroundAssociations between childhood trauma, neurodevelopment, alcohol use disorder (AUD), and posttraumatic stress disorder (PTSD) are understudied during adolescence.MethodsUsing 1652 participants (51.75% female, baseline Mage = 14.3) from the Collaborative Study of the Genetics of Alcoholism, we employed latent growth curve models to (1) examine associations of childhood physical, sexual, and non-assaultive trauma (CPAT, CSAT, and CNAT) with repeated measures of alpha band EEG coherence (EEGc), and (2) assess whether EEGc trajectories were associated with AUD and PTSD symptoms. Sex-specific models accommodated sex differences in trauma exposure, AUD prevalence, and neural development.ResultsIn females, CSAT was associated with higher mean levels of EEGc in left frontocentral (LFC, ß = 0.13, p = 0.01) and interhemispheric prefrontal (PFI, ß = 0.16, p < 0.01) regions, but diminished growth in LFC (ß = -0.07, p = 0.02) and PFI (ß = -0.07, p = 0.02). In males, CPAT was associated with lower mean levels (ß = -0.17, p = 0.01) and increased growth (ß = 0.11, p = 0.01) of LFC EEGc. Slope of LFC EEGc was inversely associated with AUD symptoms in females (ß = -1.81, p = 0.01). Intercept of right frontocentral and PFI EEGc were associated with AUD symptoms in males, but in opposite directions. Significant associations between EEGc and PTSD symptoms were also observed in trauma-exposed individuals.ConclusionsChildhood assaultive trauma is associated with changes in frontal alpha EEGc and subsequent AUD and PTSD symptoms, though patterns differ by sex and trauma type. EEGc findings may inform emerging treatments for PTSD and AUD.
Details
- Title: Subtitle
- Childhood trauma is associated with developmental trajectories of EEG coherence, alcohol-related outcomes, and PTSD symptoms
- Creators
- Zoe E NealeKaitlin BountressChristina SheerinStacey Saenz de ViteriShannon CusackDavid ChorlianPeter B BarrIsabelle KaplanGayathri PandeyKristina A OsipenkoVivia McCutcheonSally I-Chun KuoMegan E CookeSarah J BrislinJessica E SalvatoreChella KamarajanBernice PorjeszV HesselbrockT ForoudA AgrawalD DickH J EdenbergY LiuM H PlaweckiJ KramerJ MeyersA PandeyL BierutJ RiceK BucholzM SchuckitJ TischfieldR HartL AlmasyA GoateP SlesingerD ScottL BauerJ NurnbergerL WetherillX XueiD LaiS O'ConnorG ChanJ ZhangS KinreichN MullinsA AnokhinS HartzE JohnsonS SacconeJ MooreF AlievZ PangA MerikangasH ChinA ParsianTing-Kai LiP Michael ConneallyRaymond CroweWendy ReichAnanda B AmstadterCollaborative Study on the Genetics of Alcoholism (COGA) InvestigatorsS Kuperman (Contributor)
- Resource Type
- Journal article
- Publication Details
- Psychological Medicine, Vol.54(15), pp.4302-4315
- DOI
- 10.1017/S0033291724002599
- PMID
- 39620481
- PMCID
- PMC11650155
- NLM abbreviation
- Psychol Med
- ISSN
- 0033-2917
- eISSN
- 1469-8978
- Publisher
- Cambridge University Press
- Number of pages
- 4302 - 4315
- Grant note
- Genetics of Alcoholism (COGA)Indiana UniversityUniversity of Iowa Carver College of MedicineRutgers UniversityHoward UniversityNIH: U10AA008401 National Institute on Alcohol Abuse and Alcoholism (NIAAA)National Institute on Drug Abuse (NIDA)
The Collaborative Study on the Genetics of Alcoholism (COGA), Principal Investigators B. Porjesz, V. Hesselbrock, T. Foroud; Scientific Director, A. Agrawal; Translational Director, D. Dick, includes ten different centers: University of Connecticut (V. Hesselbrock); Indiana University (H.J. Edenberg, T. Foroud, Y. Liu, M.H. Plawecki); University of Iowa Carver College of Medicine (S. Kuperman, J. Kramer); SUNY Downstate Health Sciences University (B. Porjesz, J. Meyers, C. Kamarajan, A. Pandey); Washington University in St. Louis (L. Bierut, J. Rice, K. Bucholz, A. Agrawal); University of California at San Diego (M. Schuckit); Rutgers University (J. Tischfield, D. Dick, R. Hart, J. Salvatore); The Children's Hospital of Philadelphia, University of Pennsylvania (L. Almasy); Icahn School of Medicine at Mount Sinai (A. Goate, P. Slesinger); and Howard University (D. Scott). Other COGA collaborators include: L. Bauer (University of Connecticut); J. Nurnberger Jr., L. Wetherill, X., Xuei, D. Lai, S. O'Connor, (Indiana University); G. Chan (University of Iowa; University of Connecticut); D.B. Chorlian, J. Zhang, P. Barr, S. Kinreich, Z. Neale, G. Pandey (SUNY Downstate); N. Mullins (Icahn School of Medicine at Mount Sinai); A. Anokhin, S. Hartz, E. Johnson, V. McCutcheon, S. Saccone (Washington University); J. Moore, F. Aliev, Z. Pang, S. Kuo (Rutgers University); A. Merikangas (The Children's Hospital of Philadelphia and University of Pennsylvania); H. Chin and A. Parsian are the NIAAA Staff Collaborators. We continue to be inspired by our memories of Henri Begleiter and Theodore Reich, founding PI and Co-PI of COGA, and also owe a debt of gratitude to other past organizers of COGA, including Ting- Kai Li, P. Michael Conneally, Raymond Crowe, and Wendy Reich, for their critical contributions. This national collaborative study is supported by NIH Grant U10AA008401 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA).
- Language
- English
- Date published
- 11/01/2024
- Academic Unit
- Psychiatry
- Record Identifier
- 9984781272602771
Metrics
10 Record Views