Journal article
Children with hyperdiploid but not triple trisomy (+4,+10,+17) acute lymphoblastic leukemia have an increased incidence of extramedullary relapse on current therapies: A single institution experience
American journal of hematology, Vol.83(1), pp.34-40
01/01/2008
DOI: 10.1002/ajh.21011
PMID: 17696201
Abstract
To evaluate the outcome of children with high hyperdiploid acute lymphoblastic leukemia (hHDALL) treated at the author's institution. One hundred thirty-five consecutive children with B-precursor ALL were diagnosed between 1991 and 2002: 38 (28.1%) hHDALL and 97 (71.9%) non-hHDALL. In the hHDALL group, 11/38 (28.9%) relapsed at a median interval of 2.8 years (range: 0.8-5.0 years) with 9/11 relapses occurring at the end or after the completion of therapy. Three (27.3%) relapses were isolated hematopoietic (BM), while eight (72.7%) were either isolated extramedullary (EM) relapses (n = 6; Testis: 4; CNS: 2) or combined hematopoietic and extramedullary relapses (n = 2; BM + CNS: 1; BM + Testis: 1). For the non-hHDALL group, 29/97 (29.9%) relapsed. Unlike the hHDALL group, the non-hHDALL group experienced hematopoietic relapses (62%; n = 18) more frequently than isolated extramedullary (27.5%; n = 8: Testis: 1; CNS: 7) or combined hematopoietic and extramedullary relapses (10.3%; CNS + BM: 3), with 24/29 (82.8%) of the relapses occurring on therapy. Relapses in hHDALL frequently involved EM sites (P = 0.053). Presence of triple trisomy of +4,+10,+17 at diagnosis had a protective effect against relapse (P < 0.05). Five-year EFS for the hHDALL and non-hHDALL patients was similar, 70.5 +/- 7.5% and 66.4 +/- 4.9%, respectively. Five-year OS for the hHDALL patients was significantly higher than for the non-hHDALL patients, 92 +/- 4.5% vs. 74.1 +/- 4.5%, P = 0.038. Biologically significant differences exist between relapse patterns of hHDALL and non-hHDALL cases related to relapse sites and time periods when relapses occur. hDALL relapses continue to be chemo-sensitive.
Details
- Title: Subtitle
- Children with hyperdiploid but not triple trisomy (+4,+10,+17) acute lymphoblastic leukemia have an increased incidence of extramedullary relapse on current therapies: A single institution experience
- Creators
- Anjali Sharathkumar - C. S. Mott Children's HospitalDeborah DeCamillo - Children's Hospital of MichiganKanta Bhambhani - Wayne State UniversityBarbara Cushing - Wayne State UniversityRonald Thomas - Children's Hospital of MichiganAnwar N. Mohamed - Wayne State UniversityYaddanapudi Ravindranath - Children's Hospital of MichiganJeffrey W. Taub - Wayne State University
- Resource Type
- Journal article
- Publication Details
- American journal of hematology, Vol.83(1), pp.34-40
- Publisher
- Wiley
- DOI
- 10.1002/ajh.21011
- PMID
- 17696201
- ISSN
- 0361-8609
- eISSN
- 1096-8652
- Number of pages
- 7
- Language
- English
- Date published
- 01/01/2008
- Academic Unit
- Stead Family Department of Pediatrics; Hematology/Oncology
- Record Identifier
- 9984354147602771
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