Journal article
Chimeric cells of maternal origin in juvenile idiopathic inflammatory myopathies
The Lancet (British edition), Vol.356(9248), pp.2155-2156
2000
DOI: 10.1016/S0140-6736(00)03499-1
PMID: 11191545
Abstract
We identified maternal microchimerism by fluorescence in-situ hybridisation in magnetically-separated CD4 or CD8 peripheral blood cells of eight of nine male patients with juvenile idiopathic inflammatory myopathy, compared with two of nine healthy male controls. We also found maternal microchimerism in inflammatory lesions (one skin sample and nine muscle biopsy samples) of all ten patients examined, compared with two of ten biopsy samples from patients with other muscle disorders. These results suggest that maternal cells may be involved in the pathogenesis of juvenile idiopathic inflammatory myopathy.
Details
- Title: Subtitle
- Chimeric cells of maternal origin in juvenile idiopathic inflammatory myopathies
- Creators
- Carol M Artlett - Thomas Jefferson UniversityRon Ramos - Thomas Jefferson UniversitySergAio A Jiminez - Thomas Jefferson UniversityKathleen Patterson - Seattle Children's HospitalFrederick W Miller - National Institute of Arthritis and Musculoskeletal and Skin DiseasesLisa G Rider - National Institute of Arthritis and Musculoskeletal and Skin DiseasesChildhood Myositis Heterogeneity Collaborative Group
- Contributors
- Scott Vogelgesang (Contributor) - University of Iowa, Internal Medicine
- Resource Type
- Journal article
- Publication Details
- The Lancet (British edition), Vol.356(9248), pp.2155-2156
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0140-6736(00)03499-1
- PMID
- 11191545
- ISSN
- 0140-6736
- eISSN
- 1474-547X
- Language
- English
- Date published
- 2000
- Academic Unit
- Immunology; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984359958702771
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