Journal article
Chiral Polychlorinated Biphenyl Transport, Metabolism and Distribution - A Review
Environmental science & technology, Vol.44(8), pp.2757-2766
04/15/2010
DOI: 10.1021/es902208u
PMCID: PMC2855137
PMID: 20384371
Abstract
Chirality can be exploited to gain insight into enantioselective fate processes that may otherwise remain undetected because only biological, but not physical and chemical transport and transformation processes in an achiral environment will change enantiomer compositions. This review provides an in-depth overview of the application of chirality to the study of chiral polychlorinated biphenyls (PCBs), an important group of legacy pollutants. Like other chiral compounds, individual PCB enantiomers may interact enantioselectively (or enantiospecifically) with chiral macromolecules, such as cytochrome P-450 enzymes or ryanodine receptors, leading to differences in their toxicological effects and the enantioselective formation of chiral biotransformation products. Species and congener-specific enantiomer enrichment has been demonstrated in environmental compartments, wildlife and mammals, including humans, typically due to a complex combination of biotransformation processes and uptake via the diet by passive diffusion. Changes in the enantiomer composition of chiral PCBs in the environment have been used to understand complex aerobic and anaerobic microbial transformation pathways, to delineate and quantify PCB sources and transport in the environment, to gain insight into the biotransformation of PCBs in aquatic food webs, and to investigate the enantioselective disposition of PCBs and their methylsulfonyl PCBs metabolites in rodents. Overall, changes in chiral signatures are powerful, but currently underutilized tools for studies of environmental and biological processes of PCBs.
Details
- Title: Subtitle
- Chiral Polychlorinated Biphenyl Transport, Metabolism and Distribution - A Review
- Creators
- Hans-Joachim Lehmler - Environmental Studies Program and Department of Chemistry, Richardson College for the Environment, University of Winnipeg, Winnipeg, Manitoba R3B 2E9, CanadaStuart J Harrad - Environmental Studies Program and Department of Chemistry, Richardson College for the Environment, University of Winnipeg, Winnipeg, Manitoba R3B 2E9, CanadaHeinrich Hühnerfuss - Environmental Studies Program and Department of Chemistry, Richardson College for the Environment, University of Winnipeg, Winnipeg, Manitoba R3B 2E9, CanadaIzabela Kania-Korwel - Environmental Studies Program and Department of Chemistry, Richardson College for the Environment, University of Winnipeg, Winnipeg, Manitoba R3B 2E9, CanadaCindy M Lee - Environmental Studies Program and Department of Chemistry, Richardson College for the Environment, University of Winnipeg, Winnipeg, Manitoba R3B 2E9, CanadaZhe Lu - Environmental Studies Program and Department of Chemistry, Richardson College for the Environment, University of Winnipeg, Winnipeg, Manitoba R3B 2E9, CanadaCharles S Wong - Environmental Studies Program and Department of Chemistry, Richardson College for the Environment, University of Winnipeg, Winnipeg, Manitoba R3B 2E9, Canada
- Resource Type
- Journal article
- Publication Details
- Environmental science & technology, Vol.44(8), pp.2757-2766
- DOI
- 10.1021/es902208u
- PMID
- 20384371
- PMCID
- PMC2855137
- NLM abbreviation
- Environ Sci Technol
- ISSN
- 0013-936X
- eISSN
- 1520-5851
- Language
- English
- Date published
- 04/15/2010
- Academic Unit
- Occupational and Environmental Health; Iowa Neuroscience Institute; Iowa Superfund Research Program
- Record Identifier
- 9984001091302771
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